DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_COP1_1

Location: 11914:11921

E3 ligase: COP1

DEGRON score: 0.964

ASA_SCORE: 95.5125

COIL: 0.9081

CONS_SCORE: 0.3117

DSS_SCORE: 0.5552

HELIX: 0.0259

FCONS_SCORE: 0.9592

RIG_SCORE: 0.7143

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11918A	TCGA-22-5473	LUSC	TCGA	EEVEVPTV	DEG_COP1_1	0.7503
p.P11918A	DO26467	LUSC	ICGC	EEVEVPTV	DEG_COP1_1	0.7503
p.P11929H	TCGA-AA-3663	COAD	TCGA	EEVEVPTV	DEG_COP1_1	0.1111
p.P11929H	DO9346	COAD	ICGC	EEVEVPTV	DEG_COP1_1	0.1111
p.T11908I	TCGA-BC-A10Q	LIHC	TCGA	EEVEVPTV	DEG_COP1_1	0.1667
p.T11908I	TCGA-NH-A5IV	COAD	TCGA	EEVEVPTV	DEG_COP1_1	0.1667
p.T11908I	DO49095	COAD	ICGC	EEVEVPTV	DEG_COP1_1	0.1667
p.T11908I	DO22887	LIHC	ICGC	EEVEVPTV	DEG_COP1_1	0.1667
p.R11910G	TCGA-BR-8680	STAD	TCGA	EEVEVPTV	DEG_COP1_1	0.2222
p.R11910G	DO47769	STAD	ICGC	EEVEVPTV	DEG_COP1_1	0.2222
p.P11926S	TCGA-D3-A2JE	SKCM	TCGA	EEVEVPTV	DEG_COP1_1	0.1944
p.P11926S	DO219476	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	0.1944
p.E11915D	TCGA-ER-A19P	SKCM	TCGA	EEVEVPTV	DEG_COP1_1	0.5647
p.E11915D	DO47623	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	0.5647
p.P11929S	TCGA-FR-A726	SKCM	TCGA	EEVEVPTV	DEG_COP1_1	0.1111
p.P11929S	DO48665	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	0.1111
p.P11905L	DO51939	BLCA	ICGC	EEVEVPTV	DEG_COP1_1	0.0833
p.P11905L	NCI-H1092	lung	COSMIC	EEVEVPTV	DEG_COP1_1	0.0833
p.E11915K	DO50023	BRCA	ICGC	EEVEVPTV	DEG_COP1_1	0.7022
p.P11907T	DO229026	LICA	ICGC	EEVEVPTV	DEG_COP1_1	0.1389
p.P11929T	DO229036	LICA	ICGC	EEVEVPTV	DEG_COP1_1	0.1111
p.T11931N	DO229036	LICA	ICGC	EEVEVPTV	DEG_COP1_1	0.0556
p.P11919T	DO229035	LICA	ICGC	EEVEVPTV	DEG_COP1_1	0.7031
p.P11918L	DO48723	LIRI	ICGC	EEVEVPTV	DEG_COP1_1	0.7582
p.K11927N	DO26250	LUAD	ICGC	EEVEVPTV	DEG_COP1_1	0.2778
p.V11916L	DO231102	LUSC	ICGC	EEVEVPTV	DEG_COP1_1	0.5654
p.T11922P	DO45488	LUSC	ICGC	EEVEVPTV	DEG_COP1_1	0.75
p.P11929L	DO220877	MELA	ICGC	EEVEVPTV	DEG_COP1_1	0.1111
p.E11906K	DO51528	PACA	ICGC	EEVEVPTV	DEG_COP1_1	0.1111
p.E11906K	UACC-257	skin	COSMIC	EEVEVPTV	DEG_COP1_1	0.1111
p.E11925K	DO37843	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	0.2222
p.T11922I	DO223286	UCEC	ICGC	EEVEVPTV	DEG_COP1_1	0.75
p.E11905K	SIDM00129	Melanoma	GDSC	EEVEVPTV	DEG_COP1_1	0.0833
p.E11905K	G-MEL	skin	COSMIC	EEVEVPTV	DEG_COP1_1	0.0833
p.H11928Q	SIDM01196	Hepatocellular Carcinoma	GDSC	EEVEVPTV	DEG_COP1_1	0.1389
p.H11928Q	ACH-000422	Liver Cancer	CCLE	EEVEVPTV	DEG_COP1_1	0.1389
p.H11928Q	SNU-475	liver	COSMIC	EEVEVPTV	DEG_COP1_1	0.1389
p.D11905H	SK-HEP-1	liver	COSMIC	EEVEVPTV	DEG_COP1_1	0.0833
p.D11905H	ES8	bone	COSMIC	EEVEVPTV	DEG_COP1_1	0.0833
p.Y11916C	NB13	autonomic_ganglia	COSMIC	EEVEVPTV	DEG_COP1_1	0.7087
p.P11926T	Calu-3	lung	COSMIC	EEVEVPTV	DEG_COP1_1	0.1944
p.P11921L	A375	skin	COSMIC	EEVEVPTV	DEG_COP1_1	0.7582
p.P11904T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	EEVEVPTV	DEG_COP1_1	0.0556
p.R11926K	SNU-175	large_intestine	COSMIC	EEVEVPTV	DEG_COP1_1	0.1944
p.V11928M	ES1	bone	COSMIC	EEVEVPTV	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EEVEVPTV

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of EEVEVPTV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_COP1_1	11914:11921	EEVEVPTV	COP1	0.964	More...