DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_SKP2-CKS1_1

Location: 11844:11851

E3 ligase: SKP2,CSK1

DEGRON score: 0.5268

ASA_SCORE: 99.0875

COIL: 0.8698

CONS_SCORE: 0.3354

DSS_SCORE: 0.5111

HELIX: 0.0254

FCONS_SCORE: 0.9388

RIG_SCORE: 0.729

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E11860K	TCGA-38-6178	LUAD	TCGA	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E11860K	DO23842	LUAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E11860K	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E11843Q	TCGA-ZJ-AAXU	CESC	TCGA	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E11843Q	DO219759	CESC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.K11857N	DO2819	BRCA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K11857N	DO222884	COCA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R11860C	DO9002	COAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R11860C	DO48665	SKCM	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R11860C	DO50127	STAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R11860C	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K11857R	DO234270	ESAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R11860H	DO234443	ESAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R11860H	DO46657	PAAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E11846K	DO15551	HNSC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.7022
p.T11848K	DO229018	LICA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.7306
p.L11858I	DO50869	LICA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.25
p.P11842S	DO50886	LICA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E11837Q	DO26428	LUSC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S11837L	DO220874	MELA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E11843A	DO220896	MELA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E11860V	DO220903	MELA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.Q11840E	DO51171	PAEN	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P11836T	DO50075	UCEC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.V11841A	DO43306	UCEC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.25
p.E11855Q	ACH-001419	Breast Cancer	CCLE	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R11844G	SNG-M	endometrium	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.7568
p.R11844G	TGW	autonomic_ganglia	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.7568
p.P11859T	Calu-3	lung	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.T11844R	HCC1428	breast	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.7876
p.C11861F	NCI-H2227	lung	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KVELTPLK

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of KVELTPLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_SKP2-CKS1_1	11844:11851	KVELTPLK	SKP2,CSK1	0.5268	More...