DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_TRCP1_1

Location: 27021:27026

E3 ligase: BTRC

DEGRON score: 0.6035

ASA_SCORE: 56.7167

COIL: 0.567

CONS_SCORE: 0.5633

DSS_SCORE: 0.3432

HELIX: 0.0125

FCONS_SCORE: 0.9937

RIG_SCORE: 0.7545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27024L	TCGA-49-AARN	LUAD	TCGA	DSGKTT	DEG_SCF_TRCP1_1	0.7667
p.P27013A	DO48226	ESCA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.1111
p.I27029T	DO232022	LICA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.25
p.P27017R	DO23558	LUAD	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.2222
p.V27020A	DO26575	LUSC	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.3056
p.S27015F	DO232224	PBCA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.P27014L	DO229456	SKCA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.1389
p.P27034Q	DO37631	SKCM	ICGC	DSGKTT	DEG_SCF_TRCP1_1	0.1111
p.T27015A	SIDM00193	Colorectal Carcinoma	GDSC	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.T27015A	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.T27015A	SNU-81	large_intestine	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.I27032V	SIDM01099	Neuroblastoma	GDSC	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.I27032V	ACH-000341	Neuroblastoma	CCLE	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.I27032V	SK-N-FI	autonomic_ganglia	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.I27019T	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.2778
p.I27024T	SNU-1040	large_intestine	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.7078
p.M27014I	TGBC11TKB	stomach	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.1389
p.G27018C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.3611
p.A27030G	TE-4	oesophagus	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.2222
p.S27032I	NCI-H660	prostate	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.1667
p.P27024S	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_TRCP1_1	27021:27026	DSGKTT	BTRC	0.6035	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons