DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_1

Location: 34283:34288

E3 ligase: FBXW7

DEGRON score: 0.9085

ASA_SCORE: 54.6167

COIL: 0.5498

CONS_SCORE: 0.2965

DSS_SCORE: 0.3485

HELIX: 0.0088

FCONS_SCORE: 1.011

RIG_SCORE: 0.7733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R34276W	TCGA-A2-A0T0	BRCA	TCGA	PTPEVT	DEG_SCF_FBW7_1	0.1389
p.R34276W	SIDM02050	Colorectal Carcinoma	GDSC	PTPEVT	DEG_SCF_FBW7_1	0.1389
p.H34288N	TCGA-BF-A1Q0	SKCM	TCGA	PTPEVT	DEG_SCF_FBW7_1	0.7423
p.G34295C	TCGA-D3-A2JL	SKCM	TCGA	PTPEVT	DEG_SCF_FBW7_1	0.25
p.G34278R	TCGA-EO-A22U	UCEC	TCGA	PTPEVT	DEG_SCF_FBW7_1	0.1944
p.T34280K	DO3101	BRCA	ICGC	PTPEVT	DEG_SCF_FBW7_1	0.25
p.W34289L	DO47303	SKCM	ICGC	PTPEVT	DEG_SCF_FBW7_1	0.3056
p.T34288A	DO38499	STAD	ICGC	PTPEVT	DEG_SCF_FBW7_1	0.7139
p.H34297N	DO39886	THCA	ICGC	PTPEVT	DEG_SCF_FBW7_1	0.0833
p.I34296V	A375	skin	COSMIC	PTPEVT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_1	34283:34288	PTPEVT	FBXW7	0.9085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons