DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_COP1_1

Location: 33510:33519

E3 ligase: COP1

DEGRON score: 0.9306

ASA_SCORE: 61.52

COIL: 0.5655

CONS_SCORE: 0.3001

DSS_SCORE: 0.3949

HELIX: 0.004

FCONS_SCORE: 1.0172

RIG_SCORE: 0.7508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A33513V	TCGA-22-5473	LUSC	TCGA	DTDGEPVPTV	DEG_COP1_1	0.6936
p.A33513V	TCGA-AX-A1CE	UCEC	TCGA	DTDGEPVPTV	DEG_COP1_1	0.6936
p.L33505P	TCGA-BR-7851	STAD	TCGA	DTDGEPVPTV	DEG_COP1_1	0.1944
p.P33523Q	TCGA-CN-6010	HNSC	TCGA	DTDGEPVPTV	DEG_COP1_1	0.2222
p.P33523Q	TCGA-D3-A2J6	SKCM	TCGA	DTDGEPVPTV	DEG_COP1_1	0.2222
p.W33529L	TCGA-D3-A3CE	SKCM	TCGA	DTDGEPVPTV	DEG_COP1_1	0.0556
p.L33515F	TCGA-EE-A2GT	SKCM	TCGA	DTDGEPVPTV	DEG_COP1_1	0.6981
p.H33522Y	TCGA-XF-AAN2	BLCA	TCGA	DTDGEPVPTV	DEG_COP1_1	0.25
p.S33508C	DO44055	BLCA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.2778
p.D33512N	DO1071	BRCA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.6932
p.D33512N	DO26160	LUAD	ICGC	DTDGEPVPTV	DEG_COP1_1	0.6932
p.E33503K	DO223051	ESCA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.1389
p.V33519A	DO44570	LGG	ICGC	DTDGEPVPTV	DEG_COP1_1	0.5825
p.A33505E	DO229019	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.1944
p.A33505E	DO229006	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.1944
p.L33522M	DO229028	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.25
p.T33511N	DO229045	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	0.5944
p.P33517T	DO24190	LUAD	ICGC	DTDGEPVPTV	DEG_COP1_1	0.7031
p.D33510N	DO38022	SKCM	ICGC	DTDGEPVPTV	DEG_COP1_1	0.6932
p.P33515L	DO47827	STAD	ICGC	DTDGEPVPTV	DEG_COP1_1	0.6471
p.W33521C	DO38201	STAD	ICGC	DTDGEPVPTV	DEG_COP1_1	0.2778
p.K33524N	SIDM01964	Esophageal Carcinoma	GDSC	DTDGEPVPTV	DEG_COP1_1	0.3056
p.L33515V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DTDGEPVPTV	DEG_COP1_1	0.6765
p.L33515V	ACH-000914	Lymphoma	CCLE	DTDGEPVPTV	DEG_COP1_1	0.6765
p.L33515V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DTDGEPVPTV	DEG_COP1_1	0.6765
p.E33501K	IGROV-1	ovary	COSMIC	DTDGEPVPTV	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_COP1_1	33510:33519	DTDGEPVPTV	COP1	0.9306	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTDGEPVPTV

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of DTDGEPVPTV