DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_1

Location: 19277:19283

E3 ligase: FBXW7

DEGRON score: 0.5484

ASA_SCORE: 59.8143

COIL: 0.603

CONS_SCORE: 0.5082

DSS_SCORE: 0.2399

HELIX: 0.0174

FCONS_SCORE: 0.7999

RIG_SCORE: 0.8347

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19277L	SK-MEL-2	skin	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.7582
p.P19277L	COLO-792	skin	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.7582
p.P19277L	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.7582
p.P19277L	MIA-PaCa-2	pancreas	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.7582
p.T19283N	SIDM01588	Endometrial Carcinoma	GDSC	VLTPGTT	DEG_SCF_FBW7_1	0.7055
p.L19283V	NCI-H661	lung	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.6765
p.S19271P	DO46749	PAEN	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.6111
p.A19271T	TGW	autonomic_ganglia	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.6111
p.A19271T	EN	endometrium	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.6111
p.L19276P	SIDM00531	Pancreatic Carcinoma	GDSC	VLTPGTT	DEG_SCF_FBW7_1	0.3056
p.L19276P	HuP-T4	pancreas	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.3056
p.R19286H	DO234246	ESAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.R19286H	DO23717	LUAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.R19286H	DO42897	UCEC	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.R19286C	DO222440	ESCA	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.R19286C	DO45314	LUAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.M19274V	NCI-H2228	lung	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.M19274V	NCI-H1734	lung	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.V19274D	JHH-2	liver	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.25
p.I19288V	DO228305	MALY	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.1944
p.A19288T	OC-314	ovary	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	0.1944
p.D19290H	TCGA-60-2721	LUSC	TCGA	VLTPGTT	DEG_SCF_FBW7_1	0.1389
p.W19270L	DO23838	LUAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.1389
p.G19290E	DO38006	SKCM	ICGC	VLTPGTT	DEG_SCF_FBW7_1	0.1389
p.F19269C	TCGA-5S-A9Q8	UCEC	TCGA	VLTPGTT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_1	19277:19283	VLTPGTT	FBXW7	0.5484	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons