DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: LIG_APCC_ABBAyCdc20_2

Location: 33945:33951

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7093

ASA_SCORE: 91.6

COIL: 0.4661

CONS_SCORE: 0.2973

DSS_SCORE: 0.4258

HELIX: 0.2869

FCONS_SCORE: 1.0216

RIG_SCORE: 0.7724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H33937D	TCGA-63-A5MW	LUSC	TCGA	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T33949S	TCGA-UU-A93S	BRCA	TCGA	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.7116
p.Q33957K	DO229041	LICA	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A33958E	DO229045	LICA	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A33939E	DO229009	LICA	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E33944A	DO51189	LUAD	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K33936N	DO43907	UCEC	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I33935V	SIDM00454	Rhabdomyosarcoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I33935V	SIDM00650	Small Cell Lung Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I33935V	SIDM00849	Kidney Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I33935V	SIDM01681	Non-Cancerous	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I33935V	SIDM00721	Small Cell Lung Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I33935V	SIDM01387	Small Cell Lung Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T33941N	ACH-000635	Ovarian Cancer	CCLE	KSIVHEE	LIG_APCC_ABBAyCdc20_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	LIG_APCC_ABBAyCdc20_2	33945:33951	KSIVHEE	APC,CDC20,FZR1	0.7093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons