DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_APCC_KENBOX_2

Location: 13961:13965

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.515

ASA_SCORE: 102.26

COIL: 0.4072

CONS_SCORE: 0.4036

DSS_SCORE: 0.4015

HELIX: 0.0022

FCONS_SCORE: 0.9775

RIG_SCORE: 0.8083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R13953T	TCGA-17-Z031	LUAD	TCGA	FKENE	DEG_APCC_KENBOX_2	0.1111
p.G13951E	TCGA-AR-A2LH	BRCA	TCGA	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	TCGA-D6-6516	HNSC	TCGA	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	TCGA-EE-A2MN	SKCM	TCGA	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	TCGA-FR-A726	SKCM	TCGA	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	SIDM00516	Melanoma	GDSC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	SIDM00140	Melanoma	GDSC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	ACH-002166	Skin Cancer	CCLE	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	COLO-792	skin	COSMIC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.G13951E	MZ7-mel	skin	COSMIC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.V13974I	TCGA-DU-6392	LGG	TCGA	FKENE	DEG_APCC_KENBOX_2	0.0833
p.T13975M	DO13863	GBM	ICGC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.T13975M	DO47857	STAD	ICGC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.T13975M	SKN	soft_tissue	COSMIC	FKENE	DEG_APCC_KENBOX_2	0.0556
p.A13958D	DO46513	OV	ICGC	FKENE	DEG_APCC_KENBOX_2	0.25
p.P13966H	DO47839	STAD	ICGC	FKENE	DEG_APCC_KENBOX_2	0.3056
p.Y13953C	DO38192	STAD	ICGC	FKENE	DEG_APCC_KENBOX_2	0.1111
p.A13956T	SIDM00422	Hodgkin's Lymphoma	GDSC	FKENE	DEG_APCC_KENBOX_2	0.1944
p.A13956T	ACH-001203	Lymphoma	CCLE	FKENE	DEG_APCC_KENBOX_2	0.1944
p.A13956T	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	FKENE	DEG_APCC_KENBOX_2	0.1944
p.V13954G	451Lu	skin	COSMIC	FKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_APCC_KENBOX_2	13961:13965	FKENE	APC,CDC20,FZR1	0.515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons