DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_APCC_KENBOX_2

Location: 18941:18945

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.52

ASA_SCORE: 73.46

COIL: 0.571

CONS_SCORE: 0.5667

DSS_SCORE: 0.3053

HELIX: 0.0126

FCONS_SCORE: 1.0187

RIG_SCORE: 0.8346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V18946A	TCGA-AG-4022	READ	TCGA	TKENC	DEG_APCC_KENBOX_2	0.3056
p.R18933I	TCGA-AG-A002	READ	TCGA	TKENC	DEG_APCC_KENBOX_2	0.1111
p.P18938H	TCGA-BG-A222	UCEC	TCGA	TKENC	DEG_APCC_KENBOX_2	0.25
p.V18946L	TCGA-DC-6157	READ	TCGA	TKENC	DEG_APCC_KENBOX_2	0.3056
p.R18936Q	TCGA-DD-A3A6	LIHC	TCGA	TKENC	DEG_APCC_KENBOX_2	0.3056
p.R18936Q	TCGA-XV-A9W5	SKCM	TCGA	TKENC	DEG_APCC_KENBOX_2	0.3056
p.K18949N	TCGA-HF-7134	STAD	TCGA	TKENC	DEG_APCC_KENBOX_2	0.2222
p.A18941V	TCGA-NC-A5HG	LUSC	TCGA	TKENC	DEG_APCC_KENBOX_2	0.6936
p.E18950G	DO227906	COCA	ICGC	TKENC	DEG_APCC_KENBOX_2	0.1944
p.V18940E	DO21755	LAML	ICGC	TKENC	DEG_APCC_KENBOX_2	0.3056
p.T18941I	DO37806	SKCM	ICGC	TKENC	DEG_APCC_KENBOX_2	0.5966
p.K18942R	DO42023	UCEC	ICGC	TKENC	DEG_APCC_KENBOX_2	0.7237
p.E18943D	DO41133	UCEC	ICGC	TKENC	DEG_APCC_KENBOX_2	0.6758
p.T18951I	SIDM00660	Colorectal Carcinoma	GDSC	TKENC	DEG_APCC_KENBOX_2	0.1667
p.T18951I	ACH-000985	Colon/Colorectal Cancer	CCLE	TKENC	DEG_APCC_KENBOX_2	0.1667
p.T18951I	LS-411N	large_intestine	COSMIC	TKENC	DEG_APCC_KENBOX_2	0.1667
p.S18943R	HCC1806	breast	COSMIC	TKENC	DEG_APCC_KENBOX_2	0.7427
p.T18936A	HCC2998	large_intestine	COSMIC	TKENC	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NC60	Nitric oxide-associated protein 1	DEG_APCC_KENBOX_2	501:505	TKENC	APC,CDC20,FZR1	0.7112	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	18941:18945	TKENC	APC,CDC20,FZR1	0.52	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons