DegronMD

Uniprot ID: Q8NC60

Source protein: Nitric oxide-associated protein 1

Source gene: NOA1

Class: DEG_APCC_KENBOX_2

Location: 501:505

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7112

ASA_SCORE: 72

COIL: 0.7792

CONS_SCORE: 0.4118

DSS_SCORE: 0.1088

HELIX: 0.1258

FCONS_SCORE: 0.7586

RIG_SCORE: 0.8961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E503A	TCGA-A5-A0GP	UCEC	TCGA	TKENC	DEG_APCC_KENBOX_2	0.7701
p.E503A	DO41109	UCEC	ICGC	TKENC	DEG_APCC_KENBOX_2	0.7701
p.T497A	TCGA-CG-5726	STAD	TCGA	TKENC	DEG_APCC_KENBOX_2	0.2222
p.T497A	DO38483	STAD	ICGC	TKENC	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NC60	Nitric oxide-associated protein 1	DEG_APCC_KENBOX_2	501:505	TKENC	APC,CDC20,FZR1	0.7112	More...
Q8WZ42	Titin	DEG_APCC_KENBOX_2	18941:18945	TKENC	APC,CDC20,FZR1	0.52	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons