DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_2

Location: 13073:13080

E3 ligase: FBXW7

DEGRON score: 0.6448

ASA_SCORE: 66.9625

COIL: 0.588

CONS_SCORE: 0.4308

DSS_SCORE: 0.3143

HELIX: 0.0074

FCONS_SCORE: 1.0199

RIG_SCORE: 0.8056

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13072Q	TCGA-05-4410	LUAD	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.3056
p.V13084L	TCGA-63-A5MB	LUSC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.2222
p.I13088V	TCGA-66-2785	LUSC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.1111
p.P13067S	TCGA-AP-A1DK	UCEC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.2778
p.K13083N	TCGA-BF-A1Q0	SKCM	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.25
p.A13078V	TCGA-D1-A103	UCEC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.6936
p.P13068H	TCGA-EE-A2GK	SKCM	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.1944
p.V13074L	TCGA-L5-A43E	ESCA	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	0.6765
p.E13080K	DO225215	BRCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.7022
p.E13080K	DO227836	BRCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.7022
p.S13089C	DO1932	BRCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.0833
p.L13068F	DO10172	COAD	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.1944
p.L13074R	DO233271	GACA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.7316
p.L13090F	DO222494	MELA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.0556
p.L13090F	NCI-H345	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.0556
p.P13077H	DO232224	PBCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.7694
p.L13073Q	DO37631	SKCM	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	0.7765
p.E13073V	SIDM00190	Melanoma	GDSC	LLQTPDCE	DEG_SCF_FBW7_2	0.7693
p.E13073V	ACH-002097	Skin Cancer	CCLE	LLQTPDCE	DEG_SCF_FBW7_2	0.7693
p.E13073V	CP66-MEL	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.7693
p.V13077A	ACH-000107	Pancreatic Cancer	CCLE	LLQTPDCE	DEG_SCF_FBW7_2	0.6936
p.E13083K	CP50-MEL-B	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.25
p.I13081M	SNU-81	large_intestine	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.3056
p.P13077S	Mewo	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.6752
p.K13081N	KM12	large_intestine	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.3056
p.T13066I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.1389
p.P13077L	Mewo	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.7582
p.R13066M	IGROV-1	ovary	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.1389
p.H13075R	COR-L303	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.8244
p.H13075R	NCI-H1623	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.8244
p.V13070L	RERF-LC-KJ	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.25
p.A13064T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.0833
p.A13079T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.7139
p.R13089H	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLQTPDCE

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of LLQTPDCE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_2	13073:13080	LLQTPDCE	FBXW7	0.6448	More...