DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_2

Location: 9930:9935

E3 ligase: FBXW7

DEGRON score: 0.8757

ASA_SCORE: 112.5167

COIL: 0.8622

CONS_SCORE: 0.2914

DSS_SCORE: 0.6178

HELIX: 0.1062

FCONS_SCORE: 0.9428

RIG_SCORE: 0.7167

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9933L	TCGA-CZ-5465	KIRC	TCGA	MTPREE	DEG_SCF_FBW7_2	0.7667
p.S9933L	TCGA-D3-A2J7	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.7667
p.S9933L	TCGA-FS-A1ZC	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.7667
p.R9933C	DO229378	BTCA	ICGC	MTPREE	DEG_SCF_FBW7_2	0.719
p.E9935D	DO43202	UCEC	ICGC	MTPREE	DEG_SCF_FBW7_2	0.6758
p.E9934K	DO51640	CESC	ICGC	MTPREE	DEG_SCF_FBW7_2	0.591
p.S9938L	MDA-MB-453	breast	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.3611
p.E9939D	TCGA-2F-A9KQ	BLCA	TCGA	MTPREE	DEG_SCF_FBW7_2	0.3333
p.N9926K	TCGA-B5-A1MR	UCEC	TCGA	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939V	TCGA-CX-A4AQ	HNSC	TCGA	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	SIDM00695	Melanoma	GDSC	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-000322	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-002458	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-002459	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-002460	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	HT-144	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.3333
p.M9929V	C-33-A	cervix	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.3056
p.G9937E	TCGA-IH-A3EA	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.2778
p.G9937E	SIDM00007	Other Solid Cancers	GDSC	MTPREE	DEG_SCF_FBW7_2	0.2778
p.G9937E	ACH-001550	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.2778
p.G9937E	MCC13	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.2778
p.D9922N	TCGA-FZ-5923	PAAD	TCGA	MTPREE	DEG_SCF_FBW7_2	0.2222
p.I9921T	TCGA-D7-A6EV	STAD	TCGA	MTPREE	DEG_SCF_FBW7_2	0.1944
p.P9921S	NCI-H1770	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1944
p.N9940T	MFE-319	endometrium	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_2	9930:9935	MTPREE	FBXW7	0.8757	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons