DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_2

Location: 9930:9935

E3 ligase: FBXW7

DEGRON score: 0.8757

ASA_SCORE: 112.5167

COIL: 0.8622

CONS_SCORE: 0.2914

DSS_SCORE: 0.6178

HELIX: 0.1062

FCONS_SCORE: 0.9428

RIG_SCORE: 0.7167

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E9939D	TCGA-2F-A9KQ	BLCA	TCGA	MTPREE	DEG_SCF_FBW7_2	0.3333
p.N9926K	TCGA-B5-A1MR	UCEC	TCGA	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939V	TCGA-CX-A4AQ	HNSC	TCGA	MTPREE	DEG_SCF_FBW7_2	0.3333
p.S9933L	TCGA-CZ-5465	KIRC	TCGA	MTPREE	DEG_SCF_FBW7_2	0.7667
p.S9933L	TCGA-D3-A2J7	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.7667
p.S9933L	TCGA-FS-A1ZC	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.7667
p.I9921T	TCGA-D7-A6EV	STAD	TCGA	MTPREE	DEG_SCF_FBW7_2	0.1944
p.E9920K	TCGA-FW-A3R5	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.0556
p.D9922N	TCGA-FZ-5923	PAAD	TCGA	MTPREE	DEG_SCF_FBW7_2	0.2222
p.L9941M	TCGA-IB-7651	PAAD	TCGA	MTPREE	DEG_SCF_FBW7_2	0.1667
p.G9937E	TCGA-IH-A3EA	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.2778
p.G9937E	SIDM00007	Other Solid Cancers	GDSC	MTPREE	DEG_SCF_FBW7_2	0.2778
p.G9937E	ACH-001550	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.2778
p.G9937E	MCC13	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.2778
p.P9943S	TCGA-YD-A9TA	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	0.1111
p.V9923L	DO4287	BRCA	ICGC	MTPREE	DEG_SCF_FBW7_2	0.1389
p.R9933C	DO229378	BTCA	ICGC	MTPREE	DEG_SCF_FBW7_2	0.719
p.E9934K	DO51640	CESC	ICGC	MTPREE	DEG_SCF_FBW7_2	0.591
p.A9920V	DO228138	PBCA	ICGC	MTPREE	DEG_SCF_FBW7_2	0.0556
p.V9924F	DO229234	THCA	ICGC	MTPREE	DEG_SCF_FBW7_2	0.1667
p.E9935D	DO43202	UCEC	ICGC	MTPREE	DEG_SCF_FBW7_2	0.6758
p.D9945Y	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	MTPREE	DEG_SCF_FBW7_2	0.0556
p.D9945Y	ACH-000924	Lung Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.0556
p.D9945Y	NCI-H2172	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.0556
p.D9945N	SIDM01175	Other Sarcomas	GDSC	MTPREE	DEG_SCF_FBW7_2	0.0556
p.D9945N	ACH-002309	Sarcoma	CCLE	MTPREE	DEG_SCF_FBW7_2	0.0556
p.D9945N	SW684	soft_tissue	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.0556
p.E9939K	SIDM00695	Melanoma	GDSC	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-000322	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-002458	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-002459	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	ACH-002460	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	0.3333
p.E9939K	HT-144	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.3333
p.P9921S	NCI-H1770	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1944
p.N9940T	MFE-319	endometrium	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1944
p.K9943N	KYSE-150	oesophagus	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1111
p.K9943N	SH-4	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1111
p.F9942L	NCI-H1963	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.1389
p.S9938L	MDA-MB-453	breast	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.3611
p.M9929V	C-33-A	cervix	COSMIC	MTPREE	DEG_SCF_FBW7_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPREE

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of MTPREE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_2	9930:9935	MTPREE	FBXW7	0.8757	More...