DegronMD

Uniprot ID: P48431

Source protein: Transcription factor SOX-2

Source gene: SOX2

Class: DEG_ODPH_VHL_1

Location: 132:145

E3 ligase: VHL

DEGRON score: 0.9798

ASA_SCORE: 58.9571

COIL: 0.8362

CONS_SCORE: 0.3986

DSS_SCORE: 0.3498

HELIX: 0.0856

FCONS_SCORE: 0.9662

RIG_SCORE: 0.6737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K124R	TCGA-58-A46J	LUSC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.2222
p.K124R	DO45532	LUSC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.2222
p.G144R	TCGA-78-7155	LUAD	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6457
p.G144R	DO23590	LUAD	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6457
p.G144R	ACH-001369	Ovarian Cancer	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6457
p.T126M	TCGA-AJ-A3BH	UCEC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6111
p.T126M	DO41638	UCEC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6111
p.A151V	TCGA-AP-A056	UCEC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.1667
p.A151V	DO35122	PACA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.1667
p.A151V	DO43971	UCEC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.1667
p.P128S	TCGA-EO-A22X	UCEC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.2222
p.P128S	DO43907	UCEC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.2222
p.T126A	DO222994	BTCA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6111
p.N154K	DO233280	GACA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.0833
p.S138I	DO229022	LICA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.7341
p.A133S	DO229034	LICA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.7588
p.D123Y	DO229035	LICA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.0833
p.P134S	SIDM01175	Other Sarcomas	GDSC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6752
p.P134S	ACH-002309	Sarcoma	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6752
p.P134S	SW684	soft_tissue	COSMIC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.6752
p.A151T	SIDM01608	Endometrial Carcinoma	GDSC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.1667
p.A151T	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.1667
p.G135S	ACH-000419	Myeloma	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.5882
p.G135S	ACH-001541	Myeloma	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48431	Transcription factor SOX-2	DEG_ODPH_VHL_1	132:145	LAPGGNSMASGVGV	VHL	0.9798	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGGNSMASGVGV

Degron related mutations and impact score

Drug responses associated with SOX2 mutations

All proteins holding degron of LAPGGNSMASGVGV