DegronMD - Q86X10(RALGAPB)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R384Q	TCGA-05-4397	LUAD	TCGA	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.R384Q	DO25320	LUAD	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.R384Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.R384Q	ACH-000980	Lung Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.R384Q	NCI-H1155	lung	COSMIC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.E1386Q	TCGA-91-6840	LUAD	TCGA	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1111
p.E1386Q	TCGA-A2-A0YK	BRCA	TCGA	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1111
p.E1386Q	DO2836	BRCA	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1111
p.E1386Q	DO23608	LUAD	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1111
p.T1383K	TCGA-B0-4712	KIRC	TCGA	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1944
p.T1383K	DO16530	KIRC	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1944
p.E1365V	TCGA-CQ-6228	HNSC	TCGA	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.0833
p.E1365V	DO14750	HNSC	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.0833
p.R387G	DO224697	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1111
p.T379H	DO222614	COCA	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation altering degron motif	0.8521
p.S377N	DO234230	ESAD	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation altering degron motif	0.818
p.V1370A	DO233888	GACA	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.2222
p.R387L	DO229027	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1111
p.A1374S	DO229038	LICA	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation altering degron motif	0.7588
p.M370I	DO229041	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.V376F	DO229041	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation altering degron motif	0.5957
p.V1370L	DO229045	LICA	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.2222
p.I1366V	DO45261	LIRI	ICGC	ANSST	DEG_SPOP_SBC_1	1374:1378	Mutation rewiring degron network	0.1111
p.V365M	ACH-000941	Endometrial/Uterine Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556
p.V365M	ACH-000954	Endometrial/Uterine Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556
p.V365M	ACH-000973	Bladder Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556
p.V365M	ACH-001517	Endometrial/Uterine Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556
p.V365M	639-V	urinary tract	COSMIC	AVSTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556

Kaplan plot for RALGAPB in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALGAPB

UniProt ID: Q86X10

Entrez ID: 57148

Protein name: Ral GTPase-activating protein subunit beta (p170)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RALGAPB in