DegronMD

Uniprot ID: Q86X10

Source protein: Ral GTPase-activating protein subunit beta

Source gene: RALGAPB

Class: DEG_SPOP_SBC_1

Location: 1374:1378

E3 ligase: SPOP

DEGRON score: 0.5077

ASA_SCORE: 60.8

COIL: 0.7126

CONS_SCORE: 0.3605

DSS_SCORE: 0.4761

HELIX: 0.1762

FCONS_SCORE: 1.1676

RIG_SCORE: 0.7015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1386Q	TCGA-91-6840	LUAD	TCGA	ANSST	DEG_SPOP_SBC_1	0.1111
p.E1386Q	TCGA-A2-A0YK	BRCA	TCGA	ANSST	DEG_SPOP_SBC_1	0.1111
p.E1386Q	DO2836	BRCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.1111
p.E1386Q	DO23608	LUAD	ICGC	ANSST	DEG_SPOP_SBC_1	0.1111
p.T1383K	TCGA-B0-4712	KIRC	TCGA	ANSST	DEG_SPOP_SBC_1	0.1944
p.T1383K	DO16530	KIRC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1944
p.E1365V	TCGA-CQ-6228	HNSC	TCGA	ANSST	DEG_SPOP_SBC_1	0.0833
p.E1365V	DO14750	HNSC	ICGC	ANSST	DEG_SPOP_SBC_1	0.0833
p.V1370A	DO233888	GACA	ICGC	ANSST	DEG_SPOP_SBC_1	0.2222
p.A1374S	DO229038	LICA	ICGC	ANSST	DEG_SPOP_SBC_1	0.7588
p.V1370L	DO229045	LICA	ICGC	ANSST	DEG_SPOP_SBC_1	0.2222
p.I1366V	DO45261	LIRI	ICGC	ANSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75914	Serine/threonine-protein kinase PAK 3	DEG_SPOP_SBC_1	243:247	ANSST	SPOP	0.9979	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1419:1423	ANSST	SPOP	0.9956	More...
Q9H8K7	ATPase PAAT	DEG_SPOP_SBC_1	171:175	ANSST	SPOP	0.8398	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	1374:1378	ANSST	SPOP	0.5077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons