DegronMD - O75914(PAK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K425Q	TCGA-06-5416	GBM	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.2778
p.K425Q	TCGA-ER-A193	SKCM	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.2778
p.S248L	TCGA-AC-A23H	BRCA	TCGA	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.R422K	TCGA-AG-A002	READ	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1944
p.K438T	TCGA-AN-A046	BRCA	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1667
p.K438T	TCGA-BS-A0UF	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1667
p.K235Q	TCGA-E6-A1LX	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1111
p.K425N	TCGA-E6-A1LX	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.2778
p.H421N	TCGA-EE-A2GN	SKCM	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1667
p.N417T	TCGA-EO-A2CH	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation substituting flanking lysine	0.1667
p.L431P	TCGA-EO-A3B0	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.7582
p.G432E	TCGA-FW-A3R5	SKCM	TCGA	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.7199
p.A247D	TCGA-PK-A5HB	ACC	TCGA	ANSST	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7793
p.K423T	DO1285	BRCA	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.2222
p.K423T	DO41488	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.2222
p.S233L	DO2401	BRCA	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation substituting flanking lysine	0.1667
p.I251M	DO222996	BTCA	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.P435S	DO51646	CESC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation blocking phosphorylation signal	0.6944
p.R254W	DO49916	CESC	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.R254W	DO220899	MELA	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.R254W	DO41644	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.K242N	DO7783	COAD	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.C424F	DO229031	LICA	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.25
p.Y439C	DO231782	LINC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1389
p.F429L	DO230950	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.6981
p.F429L	DO224638	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.6981
p.F429L	DO43041	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.6981
p.E436K	DO231078	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation blocking phosphorylation signal	0.6667
p.R419Q	DO26460	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1111
p.R419Q	DO41211	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1111
p.R436P	DO26743	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation blocking phosphorylation signal	0.6667
p.D419N	DO220875	MELA	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1111
p.D426Y	DO50732	ORCA	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.3056
p.A246T	DO229268	THCA	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7139
p.K245R	DO229240	THCA	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7237
p.R239Q	DO42280	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.G424E	DO43090	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.25
p.G424E	DO43971	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.25
p.P435T	DO42713	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation blocking phosphorylation signal	0.6944
p.V251A	SIDM02026	Colorectal Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.L430H	SIDM00541	Colorectal Carcinoma	GDSC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.7313
p.L430H	HT55	large intestine	COSMIC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.7313
p.N428D	SIDM00660	Colorectal Carcinoma	GDSC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.6932
p.N428D	LS-411N	large intestine	COSMIC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.6932
p.V437I	SIDM00285	Neuroblastoma	GDSC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1944
p.V437I	CHP-134	autonomic ganglia	COSMIC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1944
p.R240H	SIDM01611	Endometrial Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.P237Q	ACH-000855	Esophageal Cancer	CCLE	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1667
p.P237Q	KYSE-150	oesophagus	COSMIC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1667
p.G422E	ACH-002264	Esophageal Cancer	CCLE	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1944
p.G422E	KYSE-50	oesophagus	COSMIC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1944
p.S257R	SF295	central nervous system	COSMIC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation substituting flanking lysine	0.1667
p.K243E	CCK-81	large intestine	COSMIC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7022
p.P243Q	KYSE-150	oesophagus	COSMIC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7035
p.S256R	SF295	central nervous system	COSMIC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.K242E	CCK-81	large intestine	COSMIC	ANSST	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.G428E	KYSE-50	oesophagus	COSMIC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation altering degron motif	0.7199
p.V422I	CHP-134	autonomic ganglia	COSMIC	ITPEQS	DEG_SCF_FBW7_1	427:432	Mutation rewiring degron network	0.1944

Kaplan plot for PAK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAK3

UniProt ID: O75914

Entrez ID: 5063

Protein name: Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAK3 in