DegronMD

Uniprot ID: O75914

Source protein: Serine/threonine-protein kinase PAK 3

Source gene: PAK3

Class: DEG_SPOP_SBC_1

Location: 243:247

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 79.68

COIL: 0.7634

CONS_SCORE: 0.3765

DSS_SCORE: 0.6521

HELIX: 0.222

FCONS_SCORE: 1.1866

RIG_SCORE: 0.6499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S248L	TCGA-AC-A23H	BRCA	TCGA	ANSST	DEG_SPOP_SBC_1	0.3056
p.K235Q	TCGA-E6-A1LX	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	0.1111
p.A247D	TCGA-PK-A5HB	ACC	TCGA	ANSST	DEG_SPOP_SBC_1	0.7793
p.S233L	DO2401	BRCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.1667
p.I251M	DO222996	BTCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.2222
p.R254W	DO49916	CESC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1389
p.R254W	DO220899	MELA	ICGC	ANSST	DEG_SPOP_SBC_1	0.1389
p.R254W	DO41644	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1389
p.K242N	DO7783	COAD	ICGC	ANSST	DEG_SPOP_SBC_1	0.3056
p.A246T	DO229268	THCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.7139
p.K245R	DO229240	THCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.7237
p.R239Q	DO42280	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	0.2222
p.V251A	SIDM02026	Colorectal Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.2222
p.R240H	SIDM01611	Endometrial Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.25
p.P237Q	ACH-000855	Esophageal Cancer	CCLE	ANSST	DEG_SPOP_SBC_1	0.1667
p.P237Q	KYSE-150	oesophagus	COSMIC	ANSST	DEG_SPOP_SBC_1	0.1667
p.S257R	SF295	central_nervous_system	COSMIC	ANSST	DEG_SPOP_SBC_1	0.1667
p.K243E	CCK-81	large_intestine	COSMIC	ANSST	DEG_SPOP_SBC_1	0.7022
p.P243Q	KYSE-150	oesophagus	COSMIC	ANSST	DEG_SPOP_SBC_1	0.7035
p.S256R	SF295	central_nervous_system	COSMIC	ANSST	DEG_SPOP_SBC_1	0.0833
p.K242E	CCK-81	large_intestine	COSMIC	ANSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75914	Serine/threonine-protein kinase PAK 3	DEG_SPOP_SBC_1	243:247	ANSST	SPOP	0.9979	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1419:1423	ANSST	SPOP	0.9956	More...
Q9H8K7	ATPase PAAT	DEG_SPOP_SBC_1	171:175	ANSST	SPOP	0.8398	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	1374:1378	ANSST	SPOP	0.5077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons