DegronMD - Q9H8K7(PAAT)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V163G	TCGA-43-6771	LUSC	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.V163G	DO26443	LUSC	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.G428V	TCGA-55-8302	LUAD	TCGA	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.1389
p.G428V	DO45312	LUAD	ICGC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.1389
p.G428R	TCGA-55-8302	LUAD	TCGA	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.1389
p.G428R	DO45312	LUAD	ICGC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.1389
p.G197W	TCGA-66-2742	LUSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1389
p.G197W	DO26439	LUSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1389
p.L186I	TCGA-A2-A04R	BRCA	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.7174
p.L186I	DO3620	BRCA	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.7174
p.S173C	TCGA-AC-A23H	BRCA	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7541
p.S173C	DO2401	BRCA	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.7541
p.D69N	TCGA-AJ-A3EK	UCEC	TCGA	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.1111
p.D69N	DO41584	UCEC	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.1111
p.V162A	TCGA-AJ-A3EL	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.V162A	DO41542	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.M166I	TCGA-AX-A2HC	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	TCGA-E7-A4IJ	BLCA	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	TCGA-ER-A19B	SKCM	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	TCGA-VS-A950	CESC	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	DO453	BLCA	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	DO51635	CESC	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	DO47491	SKCM	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.M166I	DO41572	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944
p.S173Y	TCGA-B5-A0JY	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.712
p.S173Y	DO43041	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.712
p.M196I	TCGA-BA-A6DA	HNSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1667
p.M196I	TCGA-CR-7389	HNSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1667
p.M196I	DO44448	HNSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1667
p.M196I	DO14190	HNSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1667
p.N64S	TCGA-BR-6452	STAD	TCGA	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.25
p.N64S	DO38404	STAD	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.25
p.R183W	TCGA-CR-7402	HNSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.8634
p.R183W	DO15727	HNSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.8634
p.T427S	TCGA-EK-A2R8	CESC	TCGA	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation blocking phosphorylation signal	0.5556
p.T427S	DO51599	CESC	ICGC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation blocking phosphorylation signal	0.5556
p.P425L	TCGA-EO-A22U	UCEC	TCGA	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.0556
p.P425L	DO43755	UCEC	ICGC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.0556
p.D435G	TCGA-IB-7651	PAAD	TCGA	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation altering degron motif	0.7198
p.D435G	DO46657	PAAD	ICGC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation altering degron motif	0.7198
p.A179G	DO10324	COAD	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.25
p.A179G	DO10324	COAD	ICGC	ANSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.S198P	DO222501	COCA	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1111
p.L440V	DO230659	LAML	ICGC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation altering degron motif	0.5654
p.L440V	SIDM00997	Thyroid Gland Carcinoma	GDSC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation altering degron motif	0.5654
p.L440V	SIDM01728	Endometrial Carcinoma	GDSC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation altering degron motif	0.5654
p.P52T	DO228947	LICA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation altering degron motif	0.5919
p.P54Q	DO228974	LICA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation altering degron motif	0.5924
p.P54S	DO229259	THCA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation altering degron motif	0.5641
p.G41C	DO229088	THCA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.1111
p.N71T	SIDM02039	Colorectal Carcinoma	GDSC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.0556
p.R445G	SIDM00733	Small Cell Lung Carcinoma	GDSC	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.2222
p.R445G	ACH-000525	Lung Cancer	CCLE	DSGERLS	DEG_SCF_TRCP1_1	435:441	Mutation rewiring degron network	0.2222
p.P40S	ACH-001638	Lymphoma	CCLE	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.0833
p.P40S	ACH-002023	Colon/Colorectal Cancer	CCLE	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.0833
p.N66S	ACH-002027	Endometrial/Uterine Cancer	CCLE	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	49:61	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAAT

UniProt ID: Q9H8K7

Entrez ID: 80007

Protein name: ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAAT in