DegronMD

Uniprot ID: Q9H8K7

Source protein: ATPase PAAT

Source gene: PAAT

Class: DEG_ODPH_VHL_1

Location: 49:61

E3 ligase: VHL

DEGRON score: 0.7198

ASA_SCORE: 57.4462

COIL: 0.6625

CONS_SCORE: 0.5188

DSS_SCORE: 0.3817

HELIX: 0.0229

FCONS_SCORE: 1.161

RIG_SCORE: 0.77

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D69N	TCGA-AJ-A3EK	UCEC	TCGA	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.1111
p.D69N	DO41584	UCEC	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.1111
p.N64S	TCGA-BR-6452	STAD	TCGA	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.25
p.N64S	DO38404	STAD	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.25
p.P52T	DO228947	LICA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.5919
p.P54Q	DO228974	LICA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.5924
p.P54S	DO229259	THCA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.5641
p.G41C	DO229088	THCA	ICGC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.1111
p.N71T	SIDM02039	Colorectal Carcinoma	GDSC	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.0556
p.P40S	ACH-001638	Lymphoma	CCLE	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.0833
p.P40S	ACH-002023	Colon/Colorectal Cancer	CCLE	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.0833
p.N66S	ACH-002027	Endometrial/Uterine Cancer	CCLE	LAPPAPGQDLVIL	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8K7	ATPase PAAT	DEG_ODPH_VHL_1	49:61	LAPPAPGQDLVIL	VHL	0.7198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons