DegronMD

Uniprot ID: Q9H8K7

Source protein: ATPase PAAT

Source gene: PAAT

Class: DEG_SCF_TRCP1_1

Location: 435:441

E3 ligase: BTRC

DEGRON score: 0.9729

ASA_SCORE: 87.8857

COIL: 0.7657

CONS_SCORE: 0.4821

DSS_SCORE: 0.706

HELIX: 0.0287

FCONS_SCORE: 1.1282

RIG_SCORE: 0.6483

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G428V	TCGA-55-8302	LUAD	TCGA	DSGERLS	DEG_SCF_TRCP1_1	0.1389
p.G428V	DO45312	LUAD	ICGC	DSGERLS	DEG_SCF_TRCP1_1	0.1389
p.G428R	TCGA-55-8302	LUAD	TCGA	DSGERLS	DEG_SCF_TRCP1_1	0.1389
p.G428R	DO45312	LUAD	ICGC	DSGERLS	DEG_SCF_TRCP1_1	0.1389
p.T427S	TCGA-EK-A2R8	CESC	TCGA	DSGERLS	DEG_SCF_TRCP1_1	0.5556
p.T427S	DO51599	CESC	ICGC	DSGERLS	DEG_SCF_TRCP1_1	0.5556
p.P425L	TCGA-EO-A22U	UCEC	TCGA	DSGERLS	DEG_SCF_TRCP1_1	0.0556
p.P425L	DO43755	UCEC	ICGC	DSGERLS	DEG_SCF_TRCP1_1	0.0556
p.D435G	TCGA-IB-7651	PAAD	TCGA	DSGERLS	DEG_SCF_TRCP1_1	0.7198
p.D435G	DO46657	PAAD	ICGC	DSGERLS	DEG_SCF_TRCP1_1	0.7198
p.L440V	DO230659	LAML	ICGC	DSGERLS	DEG_SCF_TRCP1_1	0.5654
p.L440V	SIDM00997	Thyroid Gland Carcinoma	GDSC	DSGERLS	DEG_SCF_TRCP1_1	0.5654
p.L440V	SIDM01728	Endometrial Carcinoma	GDSC	DSGERLS	DEG_SCF_TRCP1_1	0.5654
p.R445G	SIDM00733	Small Cell Lung Carcinoma	GDSC	DSGERLS	DEG_SCF_TRCP1_1	0.2222
p.R445G	ACH-000525	Lung Cancer	CCLE	DSGERLS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8K7	ATPase PAAT	DEG_SCF_TRCP1_1	435:441	DSGERLS	BTRC	0.9729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons