DegronMD

Uniprot ID: Q9H8K7

Source protein: ATPase PAAT

Source gene: PAAT

Class: DEG_APCC_DBOX_1

Location: 182:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.949

ASA_SCORE: 69.8222

COIL: 0.4233

CONS_SCORE: 0.612

DSS_SCORE: 0.3888

HELIX: 0.5481

FCONS_SCORE: 1.0561

RIG_SCORE: 0.7941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G197W	TCGA-66-2742	LUSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1389
p.G197W	DO26439	LUSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1389
p.L186I	TCGA-A2-A04R	BRCA	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	0.7174
p.L186I	DO3620	BRCA	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.7174
p.M196I	TCGA-BA-A6DA	HNSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1667
p.M196I	TCGA-CR-7389	HNSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1667
p.M196I	DO44448	HNSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1667
p.M196I	DO14190	HNSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1667
p.R183W	TCGA-CR-7402	HNSC	TCGA	SRIDLDKVQ	DEG_APCC_DBOX_1	0.8634
p.R183W	DO15727	HNSC	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.8634
p.A179G	DO10324	COAD	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.25
p.S198P	DO222501	COCA	ICGC	SRIDLDKVQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8K7	ATPase PAAT	DEG_APCC_DBOX_1	182:190	SRIDLDKVQ	APC,CDC20,FZR1	0.949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons