DegronMD

Uniprot ID: Q9H8K7

Source protein: ATPase PAAT

Source gene: PAAT

Class: DEG_SPOP_SBC_1

Location: 171:175

E3 ligase: SPOP

DEGRON score: 0.8398

ASA_SCORE: 83.28

COIL: 0.8626

CONS_SCORE: 0.3875

DSS_SCORE: 0.2481

HELIX: 0.0708

FCONS_SCORE: 0.7006

RIG_SCORE: 0.7153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V163G	TCGA-43-6771	LUSC	TCGA	ANSST	DEG_SPOP_SBC_1	0.1111
p.V163G	DO26443	LUSC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1111
p.S173C	TCGA-AC-A23H	BRCA	TCGA	ANSST	DEG_SPOP_SBC_1	0.7541
p.S173C	DO2401	BRCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.7541
p.V162A	TCGA-AJ-A3EL	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	0.0833
p.V162A	DO41542	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	0.0833
p.M166I	TCGA-AX-A2HC	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	TCGA-E7-A4IJ	BLCA	TCGA	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	TCGA-ER-A19B	SKCM	TCGA	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	TCGA-VS-A950	CESC	TCGA	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	DO453	BLCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	DO51635	CESC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	DO47491	SKCM	ICGC	ANSST	DEG_SPOP_SBC_1	0.1944
p.M166I	DO41572	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1944
p.S173Y	TCGA-B5-A0JY	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	0.712
p.S173Y	DO43041	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	0.712
p.A179G	DO10324	COAD	ICGC	ANSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75914	Serine/threonine-protein kinase PAK 3	DEG_SPOP_SBC_1	243:247	ANSST	SPOP	0.9979	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1419:1423	ANSST	SPOP	0.9956	More...
Q9H8K7	ATPase PAAT	DEG_SPOP_SBC_1	171:175	ANSST	SPOP	0.8398	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	1374:1378	ANSST	SPOP	0.5077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons