DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 1419:1423

E3 ligase: SPOP

DEGRON score: 0.9956

ASA_SCORE: 80.94

COIL: 0.9496

CONS_SCORE: 0.437

DSS_SCORE: 0.4541

HELIX: 0.0186

FCONS_SCORE: 1.1106

RIG_SCORE: 0.6598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1433L	TCGA-AA-A010	COAD	TCGA	ANSST	DEG_SPOP_SBC_1	0.0556
p.G1413E	TCGA-EO-A22X	UCEC	TCGA	ANSST	DEG_SPOP_SBC_1	0.1667
p.G1413E	DO43907	UCEC	ICGC	ANSST	DEG_SPOP_SBC_1	0.1667
p.S1412L	TCGA-KQ-A41P	BLCA	TCGA	ANSST	DEG_SPOP_SBC_1	0.1389
p.S1412L	DO223590	BLCA	ICGC	ANSST	DEG_SPOP_SBC_1	0.1389
p.A1419E	TCGA-UF-A7JO	HNSC	TCGA	ANSST	DEG_SPOP_SBC_1	0.7701
p.A1419E	DO219088	HNSC	ICGC	ANSST	DEG_SPOP_SBC_1	0.7701
p.P1411Q	DO229025	LICA	ICGC	ANSST	DEG_SPOP_SBC_1	0.1111
p.T1419A	SIDM00967	Ovarian Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.7139
p.T1419A	SIDM00971	Breast Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.7139
p.T1419A	SIDM00844	Burkitt's Lymphoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.7139
p.T1419A	SIDM00032	Bladder Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.7139
p.T1419A	SIDM01147	Gastric Carcinoma	GDSC	ANSST	DEG_SPOP_SBC_1	0.7139
p.S1423T	SIDM01689	B-Lymphoblastic Leukemia	GDSC	ANSST	DEG_SPOP_SBC_1	0.7116
p.G1413R	ACH-000985	Colon/Colorectal Cancer	CCLE	ANSST	DEG_SPOP_SBC_1	0.1667
p.S1431L	ACH-002215	Lymphoma	CCLE	ANSST	DEG_SPOP_SBC_1	0.1111
p.S1431L	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	ANSST	DEG_SPOP_SBC_1	0.1111
p.V1412M	NCI-H1155	lung	COSMIC	ANSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75914	Serine/threonine-protein kinase PAK 3	DEG_SPOP_SBC_1	243:247	ANSST	SPOP	0.9979	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1419:1423	ANSST	SPOP	0.9956	More...
Q9H8K7	ATPase PAAT	DEG_SPOP_SBC_1	171:175	ANSST	SPOP	0.8398	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	1374:1378	ANSST	SPOP	0.5077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons