DegronMD

Uniprot ID: O75914

Source protein: Serine/threonine-protein kinase PAK 3

Source gene: PAK3

Class: DEG_SCF_FBW7_1

Location: 427:432

E3 ligase: FBXW7

DEGRON score: 0.5946

ASA_SCORE: 72.95

COIL: 0.7755

CONS_SCORE: 0.4838

DSS_SCORE: 0.3268

HELIX: 0.117

FCONS_SCORE: 0.6513

RIG_SCORE: 0.7934

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K425Q	TCGA-06-5416	GBM	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.2778
p.K425Q	TCGA-ER-A193	SKCM	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.2778
p.R422K	TCGA-AG-A002	READ	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.1944
p.K438T	TCGA-AN-A046	BRCA	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.1667
p.K438T	TCGA-BS-A0UF	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.1667
p.K425N	TCGA-E6-A1LX	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.2778
p.H421N	TCGA-EE-A2GN	SKCM	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.1667
p.N417T	TCGA-EO-A2CH	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.1667
p.L431P	TCGA-EO-A3B0	UCEC	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.7582
p.G432E	TCGA-FW-A3R5	SKCM	TCGA	ITPEQS	DEG_SCF_FBW7_1	0.7199
p.K423T	DO1285	BRCA	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.2222
p.K423T	DO41488	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.2222
p.P435S	DO51646	CESC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6944
p.C424F	DO229031	LICA	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.25
p.Y439C	DO231782	LINC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.1389
p.F429L	DO230950	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6981
p.F429L	DO224638	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6981
p.F429L	DO43041	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6981
p.E436K	DO231078	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6667
p.R419Q	DO26460	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.1111
p.R419Q	DO41211	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.1111
p.R436P	DO26743	LUSC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6667
p.D419N	DO220875	MELA	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.1111
p.D426Y	DO50732	ORCA	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.3056
p.G424E	DO43090	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.25
p.G424E	DO43971	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.25
p.P435T	DO42713	UCEC	ICGC	ITPEQS	DEG_SCF_FBW7_1	0.6944
p.L430H	SIDM00541	Colorectal Carcinoma	GDSC	ITPEQS	DEG_SCF_FBW7_1	0.7313
p.L430H	HT55	large_intestine	COSMIC	ITPEQS	DEG_SCF_FBW7_1	0.7313
p.N428D	SIDM00660	Colorectal Carcinoma	GDSC	ITPEQS	DEG_SCF_FBW7_1	0.6932
p.N428D	LS-411N	large_intestine	COSMIC	ITPEQS	DEG_SCF_FBW7_1	0.6932
p.V437I	SIDM00285	Neuroblastoma	GDSC	ITPEQS	DEG_SCF_FBW7_1	0.1944
p.V437I	CHP-134	autonomic_ganglia	COSMIC	ITPEQS	DEG_SCF_FBW7_1	0.1944
p.G422E	ACH-002264	Esophageal Cancer	CCLE	ITPEQS	DEG_SCF_FBW7_1	0.1944
p.G422E	KYSE-50	oesophagus	COSMIC	ITPEQS	DEG_SCF_FBW7_1	0.1944
p.G428E	KYSE-50	oesophagus	COSMIC	ITPEQS	DEG_SCF_FBW7_1	0.7199
p.V422I	CHP-134	autonomic_ganglia	COSMIC	ITPEQS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPEQS

Degron related mutations and impact score

Drug responses associated with PAK3 mutations

All proteins holding degron of ITPEQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75914	Serine/threonine-protein kinase PAK 3	DEG_SCF_FBW7_1	427:432	ITPEQS	FBXW7	0.5946	More...
Q13153	Serine/threonine-protein kinase PAK 1	DEG_SCF_FBW7_1	414:419	ITPEQS	FBXW7	0.5946	More...