DegronMD - Q9H0E9(BRD8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A323T	TCGA-2Z-A9JS	KIRP	TCGA	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7139
p.P316Q	TCGA-FS-A1ZJ	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.A333D	DO3101	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.A333D	DO219763	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.H317N	DO229022	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.E320G	DO229453	SKCA	ICGC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.T327I	DO41361	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7078
p.V330G	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.V330G	SIDM00461	Acute Myeloid Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.T327S	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6005
p.T327S	SIDM00461	Acute Myeloid Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6005
p.T327S	Daudi	haematopoietic and lymphoid tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6005
p.P322A	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.P322A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.D337G	SIDM00282	Colorectal Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0556
p.D337G	ACH-000998	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0556
p.D337G	CW-2	large intestine	COSMIC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0556
p.S331F	KYSE-270	oesophagus	COSMIC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2222
p.M315V	LB831-BLC	urinary tract	COSMIC	AVSTT	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111

Kaplan plot for BRD8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRD8

UniProt ID: Q9H0E9

Entrez ID: 10902

Protein name: Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRD8 in