DegronMD

Uniprot ID: O95490

Source protein: Adhesion G protein-coupled receptor L2

Source gene: ADGRL2

Class: DEG_SPOP_SBC_1

Location: 429:433

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 77.8

COIL: 0.7372

CONS_SCORE: 0.4817

DSS_SCORE: 0.6576

HELIX: 0.0202

FCONS_SCORE: 1.1008

RIG_SCORE: 0.6589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G440R	SIDM00545	Melanoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.1389
p.G440R	Mewo	skin	COSMIC	PMSTT	DEG_SPOP_SBC_1	0.1389
p.S441I	SIDM01229	Neuroblastoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.5556
p.S441I	BE2-M17	autonomic_ganglia	COSMIC	PMSTT	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	429:433	PMSTT	SPOP	0.9971	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3805:3809	PMSTT	SPOP	0.9531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons