DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3805:3809

E3 ligase: SPOP

DEGRON score: 0.9531

ASA_SCORE: 91.96

COIL: 0.8536

CONS_SCORE: 0.7203

DSS_SCORE: 0.6634

HELIX: 0.0194

FCONS_SCORE: 1.1475

RIG_SCORE: 0.7114

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3815S	TCGA-AA-A00N	COAD	TCGA	PMSTT	DEG_SPOP_SBC_1	0.1667
p.L3815S	DO9876	COAD	ICGC	PMSTT	DEG_SPOP_SBC_1	0.1667
p.T3814N	TCGA-BS-A0UV	UCEC	TCGA	PMSTT	DEG_SPOP_SBC_1	0.1944
p.T3814N	DO42793	UCEC	ICGC	PMSTT	DEG_SPOP_SBC_1	0.1944
p.E3811K	TCGA-EE-A2MR	SKCM	TCGA	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811K	TCGA-FR-A7U9	SKCM	TCGA	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811K	DO222632	MELA	ICGC	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811K	DO222702	MELA	ICGC	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811K	DO48546	SKCM	ICGC	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811K	DO37819	SKCM	ICGC	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811Q	TCGA-Q1-A73O	CESC	TCGA	PMSTT	DEG_SPOP_SBC_1	0.2778
p.E3811Q	DO51612	CESC	ICGC	PMSTT	DEG_SPOP_SBC_1	0.2778
p.T3809M	DO222570	ESCA	ICGC	PMSTT	DEG_SPOP_SBC_1	0.7423
p.T3809M	SIDM01709	Melanoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.7423
p.T3809M	ACH-000275	Non-Cancerous	CCLE	PMSTT	DEG_SPOP_SBC_1	0.7423
p.L3816F	DO229029	LICA	ICGC	PMSTT	DEG_SPOP_SBC_1	0.1389
p.M3806I	DO229036	LICA	ICGC	PMSTT	DEG_SPOP_SBC_1	0.6507
p.M3806I	SIDM01126	Small Cell Lung Carcinoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.6507
p.M3806I	SIDM00846	Cervical Carcinoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.6507
p.M3806I	SIDM00633	Breast Carcinoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.6507
p.T3814I	DO222402	MELA	ICGC	PMSTT	DEG_SPOP_SBC_1	0.1944
p.T3797A	DO36556	READ	ICGC	PMSTT	DEG_SPOP_SBC_1	0.1111
p.T3801N	SIDM00555	Glioblastoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.2222
p.T3801N	SIDM00301	Pancreatic Carcinoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.2222
p.T3801N	ACH-000265	Pancreatic Cancer	CCLE	PMSTT	DEG_SPOP_SBC_1	0.2222
p.T3801N	ACH-000631	Brain Cancer	CCLE	PMSTT	DEG_SPOP_SBC_1	0.2222
p.L3798V	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PMSTT	DEG_SPOP_SBC_1	0.1389
p.L3798V	ACH-000694	Esophageal Cancer	CCLE	PMSTT	DEG_SPOP_SBC_1	0.1389
p.L3798V	TE-9	oesophagus	COSMIC	PMSTT	DEG_SPOP_SBC_1	0.1389
p.S3807L	ACH-002710	Sarcoma	CCLE	PMSTT	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	429:433	PMSTT	SPOP	0.9971	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3805:3809	PMSTT	SPOP	0.9531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PMSTT