DegronMD

Uniprot ID: Q9BTC0

Source protein: Death-inducer obliterator 1

Source gene: DIDO1

Class: LIG_APCC_ABBAyCdc20_2

Location: 782:788

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9729

ASA_SCORE: 101.4429

COIL: 0.4426

CONS_SCORE: 0.4224

DSS_SCORE: 0.64

HELIX: 0.5351

FCONS_SCORE: 1.0539

RIG_SCORE: 0.6543

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E772Q	TCGA-55-8092	LUAD	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E772Q	DO26220	LUAD	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E788K	TCGA-AC-A23H	BRCA	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E788K	TCGA-IR-A3LA	CESC	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E788K	DO2401	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E788K	DO44377	CESC	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E772K	TCGA-AC-A23H	BRCA	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E772K	DO2401	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E772K	SIDM00745	Non-Small Cell Lung Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E772K	ACH-000035	Lung Cancer	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E772K	NCI-H1650	lung	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R773S	TCGA-AP-A051	UCEC	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R773S	DO42673	UCEC	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S777F	TCGA-BF-AAP1	SKCM	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S777F	DO219464	SKCM	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P794S	TCGA-EE-A2GO	SKCM	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P794S	DO37823	SKCM	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T792K	TCGA-GS-A9TY	DLBC	TCGA	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T792K	DO219917	DLBC	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V778L	DO225280	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R776K	DO1158	BRCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E772D	DO222594	ESCA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A775E	DO229038	LICA	ICGC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A775V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A775V	ACH-000995	Leukemia	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A775V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N787S	SIDM01151	Hepatocellular Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM00535	Chondrosarcoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM00555	Glioblastoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM00193	Colorectal Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM01196	Hepatocellular Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM00489	Oral Cavity Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM00245	Small Cell Lung Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM01336	Glioblastoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.N787S	SIDM00497	Colorectal Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.5958
p.A793T	SIDM00282	Colorectal Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A793T	ACH-000998	Colon/Colorectal Cancer	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A793T	CW-2	large_intestine	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H786Y	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H786Y	ACH-000873	Esophageal Cancer	CCLE	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H786Y	KYSE-270	oesophagus	COSMIC	RTKLHNE	LIG_APCC_ABBAyCdc20_2	0.6118

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RTKLHNE

Degron related mutations and impact score

Drug responses associated with DIDO1 mutations

All proteins holding degron of RTKLHNE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTC0	Death-inducer obliterator 1	LIG_APCC_ABBAyCdc20_2	782:788	RTKLHNE	APC,CDC20,FZR1	0.9729	More...