DegronMD

Uniprot ID: Q9BTC0

Source protein: Death-inducer obliterator 1

Source gene: DIDO1

Class: DEG_SCF_FBW7_1

Location: 1253:1260

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 82.1375

COIL: 0.9764

CONS_SCORE: 0.4144

DSS_SCORE: 0.6658

HELIX: 0.0061

FCONS_SCORE: 1.2128

RIG_SCORE: 0.5092

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1258A	TCGA-83-5908	LUAD	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.6392
p.P1258A	DO23572	LUAD	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.6392
p.P1262A	TCGA-A8-A09M	BRCA	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.2778
p.P1262A	DO3852	BRCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.2778
p.C1247Y	TCGA-AX-A2HD	UCEC	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.1667
p.C1247Y	DO42608	UCEC	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.1667
p.P1262L	TCGA-B7-5816	STAD	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.2778
p.P1262L	DO38599	STAD	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.2778
p.G1259V	TCGA-DK-A3IK	BLCA	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.6421
p.G1259V	DO454	BLCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.6421
p.P1264L	TCGA-EB-A41A	SKCM	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.2222
p.P1264L	TCGA-KQ-A41N	BLCA	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.2222
p.P1264L	DO223588	BLCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.2222
p.P1264L	DO37429	SKCM	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.2222
p.P1268S	TCGA-EE-A3JA	SKCM	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.1111
p.P1268S	DO47625	SKCM	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.1111
p.P1261S	TCGA-G4-6304	COAD	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.3056
p.P1261S	DO10639	COAD	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.3056
p.P1261S	DO233168	GACA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.3056
p.S1260L	TCGA-GN-A266	SKCM	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.8778
p.S1260L	DO37432	SKCM	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.8778
p.A1249G	TCGA-KO-8408	KICH	TCGA	VSTTPPGS	DEG_SCF_FBW7_1	0.2222
p.A1249G	DO220562	KICH	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.2222
p.P1270L	DO48421	BLCA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.0556
p.S1254R	DO228976	LICA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.7427
p.P1270Q	DO229041	LICA	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.0556
p.T1256A	DO231792	LINC	ICGC	VSTTPPGS	DEG_SCF_FBW7_1	0.825
p.A1251T	SIDM00789	Colorectal Carcinoma	GDSC	VSTTPPGS	DEG_SCF_FBW7_1	0.2778
p.A1251T	ACH-000997	Colon/Colorectal Cancer	CCLE	VSTTPPGS	DEG_SCF_FBW7_1	0.2778
p.A1251T	ACH-001061	Colon/Colorectal Cancer	CCLE	VSTTPPGS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPPGS

Degron related mutations and impact score

Drug responses associated with DIDO1 mutations

All proteins holding degron of VSTTPPGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTC0	Death-inducer obliterator 1	DEG_SCF_FBW7_1	1253:1260	VSTTPPGS	FBXW7	0.9989	More...