DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPMY
Uniprot ID:
Q86VH2
Source protein:
Kinesin-like protein KIF27
Source gene:
KIF27
Class:
ITCH
Location:
608:611
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.6139
ASA_SCORE:
95.625
COIL:
0.8125
CONS_SCORE:
0.3478
DSS_SCORE:
0.3389
HELIX:
0.1365
FCONS_SCORE:
0.969
RIG_SCORE:
0.7229
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R598S
TCGA-44-2656
LUAD
TCGA
PPMY
ITCH
0.0556
p.R598S
DO26052
LUAD
ICGC
PPMY
ITCH
0.0556
p.D600Y
TCGA-A5-A2K5
UCEC
TCGA
PPMY
ITCH
0.1111
p.D600Y
DO41379
UCEC
ICGC
PPMY
ITCH
0.1111
p.R621Q
TCGA-AZ-4315
COAD
TCGA
PPMY
ITCH
0.0556
p.R621Q
TCGA-GN-A266
SKCM
TCGA
PPMY
ITCH
0.0556
p.R621Q
DO8842
COAD
ICGC
PPMY
ITCH
0.0556
p.R621Q
DO231997
ORCA
ICGC
PPMY
ITCH
0.0556
p.R621Q
DO37432
SKCM
ICGC
PPMY
ITCH
0.0556
p.R598I
TCGA-EY-A1GI
UCEC
TCGA
PPMY
ITCH
0.0556
p.R598I
DO41211
UCEC
ICGC
PPMY
ITCH
0.0556
p.P608L
TCGA-OR-A5JU
ACC
TCGA
PPMY
ITCH
0.7582
p.I616R
TCGA-US-A77E
PAAD
TCGA
PPMY
ITCH
0.1944
p.I616R
DO49416
PAAD
ICGC
PPMY
ITCH
0.1944
Drug responses associated with KIF27 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPMY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13521
Secretogranin-2
ITCH
167:170
PPMY
ITCH,NEDD4
0.519
More...
Q01954
Zinc finger protein basonuclin-1
ITCH
74:77
PPMY
ITCH,NEDD4
0.8829
More...
Q86VH2
Kinesin-like protein KIF27
ITCH
608:611
PPMY
ITCH,NEDD4
0.6139
More...
Q86WA8
Lon protease homolog 2, peroxisomal
ITCH
640:643
PPMY
ITCH,NEDD4
0.768
More...
Q96LT9
RNA-binding region-containing protein 3
ITCH
206:209
PPMY
ITCH,NEDD4
0.9928
More...
Q9HBD1
Roquin-2
ITCH
703:706
PPMY
ITCH,NEDD4
0.9939
More...
Q9HCF6
Transient receptor potential cation channel subfamily M member 3
ITCH
1515:1518
PPMY
ITCH,NEDD4
0.8817
More...
Q9NRJ4
Tubby-related protein 4
ITCH
1241:1244
PPMY
ITCH,NEDD4
0.769
More...
O15255
CAAX box protein 1
ITCH
94:97
PPMY
ITCH,NEDD4
0.956
More...
Q8NA69
Testis-expressed protein 45
ITCH
496:499
PPMY
ITCH,NEDD4
0.9984
More...
Q9P281
BAH and coiled-coil domain-containing protein 1
ITCH
901:904
PPMY
ITCH,NEDD4
0.9559
More...