DegronMD

Uniprot ID: Q9P281

Source protein: BAH and coiled-coil domain-containing protein 1

Source gene: BAHCC1

Class: ITCH

Location: 901:904

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9559

ASA_SCORE: 81.975

COIL: 0.912

CONS_SCORE: 0.2967

DSS_SCORE: 0.4886

HELIX: 0.0465

FCONS_SCORE: 0.8891

RIG_SCORE: 0.6672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G905R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPMY	ITCH	0.3056
p.G905R	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPMY	ITCH	0.3056
p.A910T	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PPMY	ITCH	0.1667
p.A910T	NCI-H2444	lung	COSMIC	PPMY	ITCH	0.1667
p.P902L	SIDM00007	Other Solid Cancers	GDSC	PPMY	ITCH	0.7582
p.P902L	MCC13	skin	COSMIC	PPMY	ITCH	0.7582
p.A891V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPMY	ITCH	0.0556
p.G906V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PPMY	ITCH	0.2778
p.G906V	KYSE-150	oesophagus	COSMIC	PPMY	ITCH	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13521	Secretogranin-2	ITCH	167:170	PPMY	ITCH,NEDD4	0.519	More...
Q01954	Zinc finger protein basonuclin-1	ITCH	74:77	PPMY	ITCH,NEDD4	0.8829	More...
Q86VH2	Kinesin-like protein KIF27	ITCH	608:611	PPMY	ITCH,NEDD4	0.6139	More...
Q86WA8	Lon protease homolog 2, peroxisomal	ITCH	640:643	PPMY	ITCH,NEDD4	0.768	More...
Q96LT9	RNA-binding region-containing protein 3	ITCH	206:209	PPMY	ITCH,NEDD4	0.9928	More...
Q9HBD1	Roquin-2	ITCH	703:706	PPMY	ITCH,NEDD4	0.9939	More...
Q9HCF6	Transient receptor potential cation channel subfamily M member 3	ITCH	1515:1518	PPMY	ITCH,NEDD4	0.8817	More...
Q9NRJ4	Tubby-related protein 4	ITCH	1241:1244	PPMY	ITCH,NEDD4	0.769	More...
O15255	CAAX box protein 1	ITCH	94:97	PPMY	ITCH,NEDD4	0.956	More...
Q8NA69	Testis-expressed protein 45	ITCH	496:499	PPMY	ITCH,NEDD4	0.9984	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	901:904	PPMY	ITCH,NEDD4	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons