DegronMD - Q86VH2(KIF27)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R598S	TCGA-44-2656	LUAD	TCGA	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.R598S	DO26052	LUAD	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.D600Y	TCGA-A5-A2K5	UCEC	TCGA	PPMY	ITCH	608:611	Mutation rewiring degron network	0.1111
p.D600Y	DO41379	UCEC	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.1111
p.K554Q	TCGA-AG-3892	READ	TCGA	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation substituting flanking lysine	0.1944
p.K554Q	DO36394	READ	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation substituting flanking lysine	0.1944
p.D569N	TCGA-AP-A1DK	UCEC	TCGA	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.2778
p.D569N	DO42033	UCEC	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.2778
p.R621Q	TCGA-AZ-4315	COAD	TCGA	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.R621Q	TCGA-GN-A266	SKCM	TCGA	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.R621Q	DO8842	COAD	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.R621Q	DO231997	ORCA	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.R621Q	DO37432	SKCM	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.L555R	TCGA-BR-4369	STAD	TCGA	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1111
p.L555R	TCGA-BR-7704	STAD	TCGA	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1111
p.L555R	DO234202	ESAD	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1111
p.L555R	DO38659	STAD	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1111
p.L555R	DO38360	STAD	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1111
p.R598I	TCGA-EY-A1GI	UCEC	TCGA	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.R598I	DO41211	UCEC	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.0556
p.N556S	TCGA-G5-6641	READ	TCGA	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1389
p.N556S	DO36909	READ	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1389
p.A573T	TCGA-HU-A4G8	STAD	TCGA	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1667
p.A573T	DO47819	STAD	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1667
p.P608L	TCGA-OR-A5JU	ACC	TCGA	PPMY	ITCH	608:611	Mutation altering degron motif	0.7582
p.I616R	TCGA-US-A77E	PAAD	TCGA	PPMY	ITCH	608:611	Mutation rewiring degron network	0.1944
p.I616R	DO49416	PAAD	ICGC	PPMY	ITCH	608:611	Mutation rewiring degron network	0.1944
p.N556K	DO231803	LINC	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1389
p.K554N	DO228338	MALY	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation substituting flanking lysine	0.1944
p.K554N	SIDM00948	Burkitt's Lymphoma	GDSC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation substituting flanking lysine	0.1944
p.K554N	ACH-002232	Lymphoma	CCLE	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation substituting flanking lysine	0.1944
p.K554N	DG-75	haematopoietic and lymphoid tissue	COSMIC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation substituting flanking lysine	0.1944
p.D572N	DO232761	PBCA	ICGC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1944
p.A573V	SIDM00581	Glioblastoma	GDSC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1667
p.A573V	ACH-000738	Brain Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1667
p.A573V	GB-1	central nervous system	COSMIC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1667
p.S562L	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.3056
p.S562L	ACH-002215	Lymphoma	CCLE	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.3056
p.S562L	BC-3	haematopoietic and lymphoid tissue	COSMIC	AKENC	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.3056

Kaplan plot for KIF27 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF27

UniProt ID: Q86VH2

Entrez ID: 55582

Protein name: Kinesin-like protein KIF27

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF27 in