DegronMD

Uniprot ID: Q86VH2

Source protein: Kinesin-like protein KIF27

Source gene: KIF27

Class: DEG_APCC_KENBOX_2

Location: 563:567

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8731

ASA_SCORE: 95.04

COIL: 0.6292

CONS_SCORE: 0.3708

DSS_SCORE: 0.4939

HELIX: 0.3458

FCONS_SCORE: 1.0687

RIG_SCORE: 0.6557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K554Q	TCGA-AG-3892	READ	TCGA	AKENC	DEG_APCC_KENBOX_2	0.1944
p.K554Q	DO36394	READ	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1944
p.D569N	TCGA-AP-A1DK	UCEC	TCGA	AKENC	DEG_APCC_KENBOX_2	0.2778
p.D569N	DO42033	UCEC	ICGC	AKENC	DEG_APCC_KENBOX_2	0.2778
p.L555R	TCGA-BR-4369	STAD	TCGA	AKENC	DEG_APCC_KENBOX_2	0.1111
p.L555R	TCGA-BR-7704	STAD	TCGA	AKENC	DEG_APCC_KENBOX_2	0.1111
p.L555R	DO234202	ESAD	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1111
p.L555R	DO38659	STAD	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1111
p.L555R	DO38360	STAD	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1111
p.N556S	TCGA-G5-6641	READ	TCGA	AKENC	DEG_APCC_KENBOX_2	0.1389
p.N556S	DO36909	READ	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1389
p.A573T	TCGA-HU-A4G8	STAD	TCGA	AKENC	DEG_APCC_KENBOX_2	0.1667
p.A573T	DO47819	STAD	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1667
p.N556K	DO231803	LINC	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1389
p.K554N	DO228338	MALY	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1944
p.K554N	SIDM00948	Burkitt's Lymphoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.1944
p.K554N	ACH-002232	Lymphoma	CCLE	AKENC	DEG_APCC_KENBOX_2	0.1944
p.K554N	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.1944
p.D572N	DO232761	PBCA	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1944
p.A573V	SIDM00581	Glioblastoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.1667
p.A573V	ACH-000738	Brain Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	0.1667
p.A573V	GB-1	central_nervous_system	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.1667
p.S562L	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.3056
p.S562L	ACH-002215	Lymphoma	CCLE	AKENC	DEG_APCC_KENBOX_2	0.3056
p.S562L	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14571	Inositol 1,4,5-trisphosphate receptor type 2	DEG_APCC_KENBOX_2	2453:2457	AKENC	APC,CDC20,FZR1	0.7072	More...
Q86VH2	Kinesin-like protein KIF27	DEG_APCC_KENBOX_2	563:567	AKENC	APC,CDC20,FZR1	0.8731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKENC

Degron related mutations and impact score

Drug responses associated with KIF27 mutations

All proteins holding degron of AKENC