DegronMD

Uniprot ID: Q14571

Source protein: Inositol 1,4,5-trisphosphate receptor type 2

Source gene: ITPR2

Class: DEG_APCC_KENBOX_2

Location: 2453:2457

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7072

ASA_SCORE: 65.2

COIL: 0.51

CONS_SCORE: 0.2074

DSS_SCORE: 0.4084

HELIX: 0.2898

FCONS_SCORE: 1.3605

RIG_SCORE: 0.7599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2444S	TCGA-13-1498	OV	TCGA	AKENC	DEG_APCC_KENBOX_2	0.0833
p.T2444S	DO30180	OV	ICGC	AKENC	DEG_APCC_KENBOX_2	0.0833
p.K2454E	TCGA-AP-A1DR	UCEC	TCGA	AKENC	DEG_APCC_KENBOX_2	0.7022
p.K2454E	DO43747	UCEC	ICGC	AKENC	DEG_APCC_KENBOX_2	0.7022
p.M2448T	TCGA-D8-A1XQ	BRCA	TCGA	AKENC	DEG_APCC_KENBOX_2	0.1944
p.M2448T	DO3095	BRCA	ICGC	AKENC	DEG_APCC_KENBOX_2	0.1944
p.A2453D	DO229028	LICA	ICGC	AKENC	DEG_APCC_KENBOX_2	0.6682
p.A2453D	DO229006	LICA	ICGC	AKENC	DEG_APCC_KENBOX_2	0.6682
p.I2461S	SIDM00174	Head and Neck Carcinoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.2222
p.I2461S	ACH-002213	Head and Neck Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	0.2222
p.I2461S	BB49-HNC	upper_aerodigestive_tract	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.2222
p.M2443T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AKENC	DEG_APCC_KENBOX_2	0.0556
p.M2443T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.0556
p.A2463V	SIDM01045	Endometrial Carcinoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.1667
p.A2463V	ACH-000978	Endometrial/Uterine Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	0.1667
p.A2463V	EN	endometrium	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.1667
p.L2445S	SIDM00685	Glioblastoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.1111
p.L2445S	ACH-000819	Brain Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	0.1111
p.L2445S	LN-18	central_nervous_system	COSMIC	AKENC	DEG_APCC_KENBOX_2	0.1111
p.P2459T	SIDM01569	Hepatocellular Carcinoma	GDSC	AKENC	DEG_APCC_KENBOX_2	0.2778
p.P2459T	ACH-000734	Liver Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14571	Inositol 1,4,5-trisphosphate receptor type 2	DEG_APCC_KENBOX_2	2453:2457	AKENC	APC,CDC20,FZR1	0.7072	More...
Q86VH2	Kinesin-like protein KIF27	DEG_APCC_KENBOX_2	563:567	AKENC	APC,CDC20,FZR1	0.8731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons