DegronMD - Q14571(ITPR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2444S	TCGA-13-1498	OV	TCGA	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.0833
p.T2444S	DO30180	OV	ICGC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.0833
p.K2454E	TCGA-AP-A1DR	UCEC	TCGA	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation altering degron motif	0.7022
p.K2454E	DO43747	UCEC	ICGC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation altering degron motif	0.7022
p.M2448T	TCGA-D8-A1XQ	BRCA	TCGA	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1944
p.M2448T	DO3095	BRCA	ICGC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1944
p.A2453D	DO229028	LICA	ICGC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation altering degron motif	0.6682
p.A2453D	DO229006	LICA	ICGC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation altering degron motif	0.6682
p.I2461S	SIDM00174	Head and Neck Carcinoma	GDSC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.2222
p.I2461S	ACH-002213	Head and Neck Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.2222
p.I2461S	BB49-HNC	upper aerodigestive tract	COSMIC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.2222
p.M2443T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.0556
p.M2443T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.0556
p.A2463V	SIDM01045	Endometrial Carcinoma	GDSC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1667
p.A2463V	ACH-000978	Endometrial/Uterine Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1667
p.A2463V	EN	endometrium	COSMIC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1667
p.L2445S	SIDM00685	Glioblastoma	GDSC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1111
p.L2445S	ACH-000819	Brain Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1111
p.L2445S	LN-18	central nervous system	COSMIC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.1111
p.P2459T	SIDM01569	Hepatocellular Carcinoma	GDSC	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.2778
p.P2459T	ACH-000734	Liver Cancer	CCLE	AKENC	DEG_APCC_KENBOX_2	2453:2457	Mutation rewiring degron network	0.2778

Kaplan plot for ITPR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITPR2

UniProt ID: Q14571

Entrez ID: 3709

Protein name: Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITPR2 in