DegronMD

Uniprot ID: Q9NQ76

Source protein: Matrix extracellular phosphoglycoprotein

Source gene: MEPE

Class: DEG_APCC_DBOX_1

Location: 173:181

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 79.6556

COIL: 0.7118

CONS_SCORE: 0.7158

DSS_SCORE: 0.514

HELIX: 0.1629

FCONS_SCORE: 1.1823

RIG_SCORE: 0.7945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y186H	TCGA-43-2578	LUSC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.1944
p.L164M	TCGA-99-8028	LUAD	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.0833
p.L164M	SNU-175	large_intestine	COSMIC	PRNVLNIIP	DEG_APCC_DBOX_1	0.0833
p.N178S	TCGA-A5-A2K5	UCEC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.5958
p.N178S	DO41379	UCEC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.5958
p.S191L	TCGA-AZ-4315	COAD	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.0556
p.H190Q	TCGA-D1-A0ZO	UCEC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.0833
p.E166K	TCGA-RP-A694	SKCM	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.1389
p.E166K	DO51269	SKCM	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.1389
p.E167K	TCGA-UF-A7JA	HNSC	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.1667
p.E166D	TCGA-VQ-A91S	STAD	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.1389
p.I179L	TCGA-YD-A89C	SKCM	TCGA	PRNVLNIIP	DEG_APCC_DBOX_1	0.6063
p.I179L	DO219501	SKCM	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.6063
p.S167L	DO8842	COAD	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.1667
p.R191C	DO233265	GACA	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.0556
p.E167G	DO229237	LMS	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.1667
p.S182R	DO230968	LUSC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.3056
p.S182R	DO224621	LUSC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.3056
p.R175K	DO47389	SKCM	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.7237
p.H166Q	DO41927	UCEC	ICGC	PRNVLNIIP	DEG_APCC_DBOX_1	0.1389
p.A191V	SIDM00013	Melanoma	GDSC	PRNVLNIIP	DEG_APCC_DBOX_1	0.0556
p.Q183K	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PRNVLNIIP	DEG_APCC_DBOX_1	0.2778
p.Q183K	NCI-H1568	lung	COSMIC	PRNVLNIIP	DEG_APCC_DBOX_1	0.2778
p.H190Y	ACH-000954	Endometrial/Uterine Cancer	CCLE	PRNVLNIIP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_DBOX_1	173:181	PRNVLNIIP	APC,CDC20,FZR1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons