DegronMD

Uniprot ID: Q9NQ76

Source protein: Matrix extracellular phosphoglycoprotein

Source gene: MEPE

Class: DEG_APCC_KENBOX_2

Location: 104:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9952

ASA_SCORE: 91.8

COIL: 0.6648

CONS_SCORE: 0.5976

DSS_SCORE: 0.498

HELIX: 0.2798

FCONS_SCORE: 1.3092

RIG_SCORE: 0.6739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G111C	TCGA-50-5049	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.25
p.G111C	DO229022	LICA	ICGC	NKENT	DEG_APCC_KENBOX_2	0.25
p.G111C	DO23705	LUAD	ICGC	NKENT	DEG_APCC_KENBOX_2	0.25
p.T108S	TCGA-50-6593	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.6005
p.T108S	DO24100	LUAD	ICGC	NKENT	DEG_APCC_KENBOX_2	0.6005
p.E106D	TCGA-A5-A2K5	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.6758
p.E106D	TCGA-BS-A0UV	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.6758
p.L96M	TCGA-AP-A051	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.1111
p.L96M	DO42673	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1111
p.P118H	TCGA-D3-A2JC	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	0.0556
p.S101I	TCGA-NC-A5HD	LUSC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.25
p.S101I	DO219184	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.25
p.E99K	DO10172	COAD	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1944
p.N107I	DO222843	MELA	ICGC	NKENT	DEG_APCC_KENBOX_2	0.728
p.K100R	DO36619	READ	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2222
p.P94H	DO47578	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.0556
p.T97I	DO38111	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1389
p.D107N	DO51298	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.6932
p.F102V	DO42280	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2778
p.R99S	SIDM00401	Melanoma	GDSC	NKENT	DEG_APCC_KENBOX_2	0.1944
p.R99S	RVH-421	skin	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.1944
p.G113R	SIDM01175	Other Sarcomas	GDSC	NKENT	DEG_APCC_KENBOX_2	0.1944
p.G113R	SW684	soft_tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.1944
p.A94T	ACH-000999	Colon/Colorectal Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	0.0556
p.A94T	SNU-1040	large_intestine	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.0556
p.N104D	ACH-002317	Leukemia	CCLE	NKENT	DEG_APCC_KENBOX_2	0.5821
p.N104D	YT	haematopoietic_and_lymphoid_tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	104:108	NKENT	APC,CDC20,FZR1	0.9952	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	168:172	NKENT	APC,CDC20,FZR1	0.8651	More...
O94988	Protein FAM13A	DEG_APCC_KENBOX_2	428:432	NKENT	APC,CDC20,FZR1	0.9473	More...
Q8TBY0	Probable RNA-binding protein 46	DEG_APCC_KENBOX_2	310:314	NKENT	APC,CDC20,FZR1	0.8004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENT

Degron related mutations and impact score

Drug responses associated with MEPE mutations

All proteins holding degron of NKENT