DegronMD - Q8TBY0(RBM46)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P308L	TCGA-75-6211	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.2778
p.P308L	DO25173	LUAD	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.2778
p.S300N	TCGA-A5-A1OF	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.0556
p.S300N	DO42568	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.0556
p.S300G	TCGA-AA-A010	COAD	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.0556
p.A306V	TCGA-EO-A22R	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.2222
p.A306V	DO42713	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.2222
p.I301S	TCGA-EO-A22X	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.0833
p.I301S	DO43907	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.0833
p.K307T	TCGA-ER-A193	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation substituting flanking lysine	0.3611
p.K307T	DO47368	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation substituting flanking lysine	0.3611
p.G321C	TCGA-ER-A19N	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.1389
p.G321C	DO37452	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.1389
p.E312K	TCGA-F5-6814	READ	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation altering degron motif	0.7022
p.E312K	DO36556	READ	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation altering degron motif	0.7022
p.R316K	TCGA-FR-A3YN	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.2778
p.R316K	DO38111	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.2778
p.K311N	SIDM00120	Prostate Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation altering degron motif	0.6918
p.K311N	ACH-000979	Prostate Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation altering degron motif	0.6918
p.K311N	DU-145	prostate	COSMIC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation altering degron motif	0.6918
p.Q317L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.25
p.Q317L	ACH-000912	Lung Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	310:314	Mutation rewiring degron network	0.25

Kaplan plot for RBM46 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM46

UniProt ID: Q8TBY0

Entrez ID: 166863

Protein name: Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM46 in