DegronMD

Uniprot ID: Q8TBY0

Source protein: Probable RNA-binding protein 46

Source gene: RBM46

Class: DEG_APCC_KENBOX_2

Location: 310:314

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8004

ASA_SCORE: 103.02

COIL: 0.5436

CONS_SCORE: 0.663

DSS_SCORE: 0.3942

HELIX: 0.4522

FCONS_SCORE: 1.0156

RIG_SCORE: 0.772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P308L	TCGA-75-6211	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.2778
p.P308L	DO25173	LUAD	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2778
p.S300N	TCGA-A5-A1OF	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.0556
p.S300N	DO42568	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.0556
p.S300G	TCGA-AA-A010	COAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.0556
p.A306V	TCGA-EO-A22R	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.2222
p.A306V	DO42713	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2222
p.I301S	TCGA-EO-A22X	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.0833
p.I301S	DO43907	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.0833
p.K307T	TCGA-ER-A193	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	0.3611
p.K307T	DO47368	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.3611
p.G321C	TCGA-ER-A19N	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	0.1389
p.G321C	DO37452	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1389
p.E312K	TCGA-F5-6814	READ	TCGA	NKENT	DEG_APCC_KENBOX_2	0.7022
p.E312K	DO36556	READ	ICGC	NKENT	DEG_APCC_KENBOX_2	0.7022
p.R316K	TCGA-FR-A3YN	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	0.2778
p.R316K	DO38111	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2778
p.K311N	SIDM00120	Prostate Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	0.6918
p.K311N	ACH-000979	Prostate Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	0.6918
p.K311N	DU-145	prostate	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.6918
p.Q317L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	0.25
p.Q317L	ACH-000912	Lung Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	104:108	NKENT	APC,CDC20,FZR1	0.9952	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	168:172	NKENT	APC,CDC20,FZR1	0.8651	More...
O94988	Protein FAM13A	DEG_APCC_KENBOX_2	428:432	NKENT	APC,CDC20,FZR1	0.9473	More...
Q8TBY0	Probable RNA-binding protein 46	DEG_APCC_KENBOX_2	310:314	NKENT	APC,CDC20,FZR1	0.8004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons