DegronMD

Uniprot ID: Q9NQ76

Source protein: Matrix extracellular phosphoglycoprotein

Source gene: MEPE

Class: DEG_APCC_KENBOX_2

Location: 168:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8651

ASA_SCORE: 99.44

COIL: 0.763

CONS_SCORE: 0.6759

DSS_SCORE: 0.3916

HELIX: 0.079

FCONS_SCORE: 1.0479

RIG_SCORE: 0.7164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A160S	TCGA-38-4631	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.1111
p.L164M	TCGA-99-8028	LUAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.2222
p.L164M	SNU-175	large_intestine	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.2222
p.I161V	TCGA-AX-A06F	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.1389
p.I161V	DO41752	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1389
p.A160V	TCGA-DF-A2KV	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.1111
p.A160V	TCGA-QS-A5YQ	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.1111
p.A160V	DO222884	COCA	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1111
p.A160V	DO228544	GACA	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1111
p.A160V	DO219771	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1111
p.A160V	DO49073	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.1111
p.E166K	TCGA-RP-A694	SKCM	TCGA	NKENT	DEG_APCC_KENBOX_2	0.2778
p.E166K	DO51269	SKCM	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2778
p.E167K	TCGA-UF-A7JA	HNSC	TCGA	NKENT	DEG_APCC_KENBOX_2	0.3056
p.E166D	TCGA-VQ-A91S	STAD	TCGA	NKENT	DEG_APCC_KENBOX_2	0.2778
p.K171T	DO7801	COAD	ICGC	NKENT	DEG_APCC_KENBOX_2	0.7306
p.S167L	DO8842	COAD	ICGC	NKENT	DEG_APCC_KENBOX_2	0.3056
p.A158S	DO229029	LICA	ICGC	NKENT	DEG_APCC_KENBOX_2	0.0556
p.E167G	DO229237	LMS	ICGC	NKENT	DEG_APCC_KENBOX_2	0.3056
p.S182R	DO230968	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.0556
p.S182R	DO224621	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.0556
p.Y162H	DO26662	LUSC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2778
p.D169N	DO222743	MELA	ICGC	NKENT	DEG_APCC_KENBOX_2	0.6932
p.H166Q	DO41927	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	0.2778
p.I168S	H513	pleura	COSMIC	NKENT	DEG_APCC_KENBOX_2	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	104:108	NKENT	APC,CDC20,FZR1	0.9952	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_APCC_KENBOX_2	168:172	NKENT	APC,CDC20,FZR1	0.8651	More...
O94988	Protein FAM13A	DEG_APCC_KENBOX_2	428:432	NKENT	APC,CDC20,FZR1	0.9473	More...
Q8TBY0	Probable RNA-binding protein 46	DEG_APCC_KENBOX_2	310:314	NKENT	APC,CDC20,FZR1	0.8004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons