DegronMD

Uniprot ID: Q8IYG6

Source protein: Leucine-rich repeat-containing protein 56

Source gene: LRRC56

Class: SCF_FBXL2

Location: 472:480

E3 ligase: FBXL2

DEGRON score: 0.9729

ASA_SCORE: 79.3111

COIL: 0.6153

CONS_SCORE: 0.3589

DSS_SCORE: 0.4656

HELIX: 0.2637

FCONS_SCORE: 1.2185

RIG_SCORE: 0.726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D471G	TCGA-BR-8680	STAD	TCGA	LQSRGRRLR	SCF_FBXL2	0.3056
p.D471G	DO47769	STAD	ICGC	LQSRGRRLR	SCF_FBXL2	0.3056
p.Q473K	TCGA-CR-7367	HNSC	TCGA	LQSRGRRLR	SCF_FBXL2	0.6944
p.Q473K	DO15999	HNSC	ICGC	LQSRGRRLR	SCF_FBXL2	0.6944
p.P466L	TCGA-D3-A2JL	SKCM	TCGA	LQSRGRRLR	SCF_FBXL2	0.1667
p.P466L	DO47278	SKCM	ICGC	LQSRGRRLR	SCF_FBXL2	0.1667
p.R480L	TCGA-EE-A2MK	SKCM	TCGA	LQSRGRRLR	SCF_FBXL2	0.7316
p.R480L	DO38177	SKCM	ICGC	LQSRGRRLR	SCF_FBXL2	0.7316
p.Q473E	TCGA-FI-A3PX	UCEC	TCGA	LQSRGRRLR	SCF_FBXL2	0.6744
p.Q473E	DO52417	UCEC	ICGC	LQSRGRRLR	SCF_FBXL2	0.6744
p.R477C	TCGA-HU-A4GU	STAD	TCGA	LQSRGRRLR	SCF_FBXL2	0.719
p.R477C	DO47849	STAD	ICGC	LQSRGRRLR	SCF_FBXL2	0.719
p.R477C	SIDM02015	Colorectal Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	0.719
p.R467Q	DO229480	LAML	ICGC	LQSRGRRLR	SCF_FBXL2	0.1944
p.R467Q	DO230993	LUSC	ICGC	LQSRGRRLR	SCF_FBXL2	0.1944
p.R467W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	0.1944
p.R467W	ACH-000980	Lung Cancer	CCLE	LQSRGRRLR	SCF_FBXL2	0.1944
p.R467W	NCI-H1155	lung	COSMIC	LQSRGRRLR	SCF_FBXL2	0.1944
p.W485L	SIDM01617	Endometrial Carcinoma	GDSC	LQSRGRRLR	SCF_FBXL2	0.1944
p.W485L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LQSRGRRLR	SCF_FBXL2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYG6	Leucine-rich repeat-containing protein 56	SCF_FBXL2	472:480	LQSRGRRLR	FBXL2	0.9729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons