DegronMD

Uniprot ID: Q9Y4G8

Source protein: Rap guanine nucleotide exchange factor 2

Source gene: RAPGEF2

Class: DEG_SCF_TRCP1_1

Location: 1243:1248

E3 ligase: BTRC

DEGRON score: 0.9965

ASA_SCORE: 59.85

COIL: 0.8975

CONS_SCORE: 0.3649

DSS_SCORE: 0.5162

HELIX: 0.0558

FCONS_SCORE: 1.04

RIG_SCORE: 0.5842

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1242S	TCGA-24-2295	OV	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.3056
p.A1242S	DO32173	OV	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.3056
p.C1252S	TCGA-44-A4SS	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.2222
p.C1252S	DO24227	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.2222
p.S1244I	TCGA-55-A491	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.8453
p.S1244I	DO25787	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.8453
p.G1245C	TCGA-55-A491	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.76
p.G1245C	DO25787	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.76
p.D1240H	TCGA-75-6214	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.25
p.D1240H	DO24830	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.25
p.R1236C	TCGA-90-A4ED	LUSC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	TCGA-EE-A2MR	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	TCGA-FW-A3R5	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	TCGA-G4-6586	COAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	DO9698	COAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	DO45482	LUSC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	DO37819	SKCM	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	DO37406	SKCM	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	SIDM00487	Colorectal Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	ACH-000963	Colon/Colorectal Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1236C	CCK-81	large_intestine	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.A1237T	TCGA-AA-3864	COAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.A1237T	DO8490	COAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.A1237T	SIDM00216	Colorectal Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.A1237T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.A1237T	SNU-175	large_intestine	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.D1258A	TCGA-AX-A0J0	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.D1258A	DO41133	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.R1246S	TCGA-NH-A5IV	COAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.6316
p.R1246S	DO49095	COAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.6316
p.A1237V	DO230326	COCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.R1236L	DO229045	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.R1246C	SIDM00472	Ovarian Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.719
p.R1246C	ACH-001630	Ovarian Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	0.719
p.R1246C	PEO1	ovary	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16471	Prolactin receptor	DEG_SCF_TRCP1_1	348:353	DSGRGS	BTRC	0.9988	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SCF_TRCP1_1	1359:1364	DSGRGS	BTRC	0.9746	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	1243:1248	DSGRGS	BTRC	0.9965	More...
Q8N398	von Willebrand factor A domain-containing protein 5B2	DEG_SCF_TRCP1_1	1141:1146	DSGRGS	BTRC	0.7446	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRGS

Degron related mutations and impact score

Drug responses associated with RAPGEF2 mutations

All proteins holding degron of DSGRGS