DegronMD - Q8N398(VWA5B2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H974N	TCGA-AX-A3G8	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.25
p.H974N	DO41014	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.25
p.P981H	TCGA-D1-A176	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.0556
p.P981H	DO43947	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.0556
p.A978D	TCGA-DF-A2KU	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.1389
p.A978D	DO223286	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.1389
p.P969L	TCGA-LN-A49M	ESCA	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation altering degron motif	0.6471
p.S1131G	DO230311	COCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1141:1146	Mutation rewiring degron network	0.0556
p.A977S	DO229026	LICA	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.1667
p.G1153V	DO25847	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1141:1146	Mutation rewiring degron network	0.1389
p.P969A	DO50726	ORCA	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation altering degron motif	0.6392
p.A962T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.2778
p.A962T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.2778
p.G966E	SIDM00640	Mesothelioma	GDSC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation altering degron motif	0.6087
p.G966E	SIDM00079	Ovarian Carcinoma	GDSC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation altering degron motif	0.6087
p.K975R	RKO	large intestine	COSMIC	PPGTPPAS	DEG_SCF_FBW7_1	964:971	Mutation rewiring degron network	0.2222

Kaplan plot for VWA5B2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWA5B2

UniProt ID: Q8N398

Entrez ID: 90113

Protein name: von Willebrand factor A domain-containing protein 5B2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWA5B2 in