DegronMD

Uniprot ID: Q8N398

Source protein: von Willebrand factor A domain-containing protein 5B2

Source gene: VWA5B2

Class: DEG_SCF_FBW7_1

Location: 964:971

E3 ligase: FBXW7

DEGRON score: 0.9679

ASA_SCORE: 64.8

COIL: 0.9035

CONS_SCORE: 0.4338

DSS_SCORE: 0.6902

HELIX: 0.0651

FCONS_SCORE: 1.0808

RIG_SCORE: 0.5197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H974N	TCGA-AX-A3G8	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.25
p.H974N	DO41014	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.25
p.P981H	TCGA-D1-A176	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.0556
p.P981H	DO43947	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.0556
p.A978D	TCGA-DF-A2KU	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.1389
p.A978D	DO223286	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.1389
p.P969L	TCGA-LN-A49M	ESCA	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.6471
p.A977S	DO229026	LICA	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.1667
p.P969A	DO50726	ORCA	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.6392
p.A962T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPGTPPAS	DEG_SCF_FBW7_1	0.2778
p.A962T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPPAS	DEG_SCF_FBW7_1	0.2778
p.G966E	SIDM00640	Mesothelioma	GDSC	PPGTPPAS	DEG_SCF_FBW7_1	0.6087
p.G966E	SIDM00079	Ovarian Carcinoma	GDSC	PPGTPPAS	DEG_SCF_FBW7_1	0.6087
p.K975R	RKO	large_intestine	COSMIC	PPGTPPAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SCF_FBW7_1	610:617	PPGTPPAS	FBXW7	0.9979	More...
Q8N398	von Willebrand factor A domain-containing protein 5B2	DEG_SCF_FBW7_1	964:971	PPGTPPAS	FBXW7	0.9679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons