DegronMD

Uniprot ID: O60343

Source protein: TBC1 domain family member 4

Source gene: TBC1D4

Class: DEG_SCF_FBW7_1

Location: 610:617

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 80.3125

COIL: 0.9683

CONS_SCORE: 0.3508

DSS_SCORE: 0.82

HELIX: 0.0109

FCONS_SCORE: 1.1314

RIG_SCORE: 0.4484

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S609F	TCGA-AC-A23C	BRCA	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.75
p.S609F	DO3626	BRCA	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.75
p.A622V	TCGA-AX-A2HD	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.1944
p.A622V	DO42608	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.1944
p.P614L	TCGA-B5-A3FA	UCEC	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.7582
p.P614L	DO52402	UCEC	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.7582
p.G607W	TCGA-BF-A1PZ	SKCM	TCGA	PPGTPPAS	DEG_SCF_FBW7_1	0.25
p.G607W	DO50279	SKCM	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.25
p.P619L	DO234285	ESAD	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.2778
p.P606T	DO229019	LICA	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.2222
p.W623S	DO46493	OV	ICGC	PPGTPPAS	DEG_SCF_FBW7_1	0.1667
p.T625M	ACH-001688	Kidney Cancer	CCLE	PPGTPPAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SCF_FBW7_1	610:617	PPGTPPAS	FBXW7	0.9979	More...
Q8N398	von Willebrand factor A domain-containing protein 5B2	DEG_SCF_FBW7_1	964:971	PPGTPPAS	FBXW7	0.9679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons