DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGRGS
Uniprot ID:
Q8N398
Source protein:
von Willebrand factor A domain-containing protein 5B2
Source gene:
VWA5B2
Class:
DEG_SCF_TRCP1_1
Location:
1141:1146
E3 ligase:
BTRC
DEGRON score:
0.7446
ASA_SCORE:
66.5667
COIL:
0.8713
CONS_SCORE:
0.3896
DSS_SCORE:
0.8037
HELIX:
0.0847
FCONS_SCORE:
0.8061
RIG_SCORE:
0.5427
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1131G
DO230311
COCA
ICGC
DSGRGS
DEG_SCF_TRCP1_1
0.0556
p.G1153V
DO25847
LUAD
ICGC
DSGRGS
DEG_SCF_TRCP1_1
0.1389
Drug responses associated with VWA5B2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGRGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P16471
Prolactin receptor
DEG_SCF_TRCP1_1
348:353
DSGRGS
BTRC
0.9988
More...
Q8TEU7
Rap guanine nucleotide exchange factor 6
DEG_SCF_TRCP1_1
1359:1364
DSGRGS
BTRC
0.9746
More...
Q9Y4G8
Rap guanine nucleotide exchange factor 2
DEG_SCF_TRCP1_1
1243:1248
DSGRGS
BTRC
0.9965
More...
Q8N398
von Willebrand factor A domain-containing protein 5B2
DEG_SCF_TRCP1_1
1141:1146
DSGRGS
BTRC
0.7446
More...