DegronMD

Uniprot ID: Q9Y4G8

Source protein: Rap guanine nucleotide exchange factor 2

Source gene: RAPGEF2

Class: DEG_SPOP_SBC_1

Location: 1356:1360

E3 ligase: SPOP

DEGRON score: 0.9966

ASA_SCORE: 78.74

COIL: 0.8064

CONS_SCORE: 0.359

DSS_SCORE: 0.5562

HELIX: 0.1544

FCONS_SCORE: 1.1647

RIG_SCORE: 0.6792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1346L	TCGA-73-4662	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	0.0556
p.R1346L	DO24790	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	0.0556
p.G1348S	TCGA-D3-A8GM	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	0.1111
p.G1348S	DO50288	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	0.1111
p.S1353Y	TCGA-EX-A1H6	CESC	TCGA	AESSS	DEG_SPOP_SBC_1	0.25
p.S1353Y	DO44308	CESC	ICGC	AESSS	DEG_SPOP_SBC_1	0.25
p.T1369A	TCGA-OR-A5LK	ACC	TCGA	AESSS	DEG_SPOP_SBC_1	0.0833
p.R1346W	DO218180	ORCA	ICGC	AESSS	DEG_SPOP_SBC_1	0.0556
p.T1366M	SIDM02049	Pancreatic Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.1667
p.T1366M	SIDM00662	Melanoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.1667
p.T1366M	SIDM00188	Kidney Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.1667
p.T1366M	SIDM01711	Non-Cancerous	GDSC	AESSS	DEG_SPOP_SBC_1	0.1667
p.T1366M	Hs940-T	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	0.1667
p.R1347S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.0833
p.R1347S	ACH-000917	Esophageal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.0833
p.R1347S	TE-4	oesophagus	COSMIC	AESSS	DEG_SPOP_SBC_1	0.0833
p.L1361P	SIDM01608	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	0.3056
p.L1361P	ACH-000990	Endometrial/Uterine Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.3056
p.T1362R	ACH-000836	Head and Neck Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	0.2778
p.S1361C	SK-LU-1	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D2B8	Putative postmeiotic segregation increased 2-like protein 1	DEG_SPOP_SBC_1	204:208	AESSS	SPOP	0.7952	More...
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	39:43	AESSS	SPOP	0.9974	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	531:535	AESSS	SPOP	0.9433	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	1071:1075	AESSS	SPOP	0.994	More...
O95425	Supervillin	DEG_SPOP_SBC_1	224:228	AESSS	SPOP	0.9913	More...
P21127	Cyclin-dependent kinase 11B	DEG_SPOP_SBC_1	292:296	AESSS	SPOP	0.9672	More...
P21802	Fibroblast growth factor receptor 2	DEG_SPOP_SBC_1	432:436	AESSS	SPOP	0.9911	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	509:513	AESSS	SPOP	0.6044	More...
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1	DEG_SPOP_SBC_1	412:416	AESSS	SPOP	0.8001	More...
Q0JRZ9	F-BAR domain only protein 2	DEG_SPOP_SBC_1	506:510	AESSS	SPOP	0.9995	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	218:222	AESSS	SPOP	0.504	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1450:1454	AESSS	SPOP	0.9979	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	359:363	AESSS	SPOP	0.9466	More...
Q15054	DNA polymerase delta subunit 3	DEG_SPOP_SBC_1	146:150	AESSS	SPOP	0.8262	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	3437:3441	AESSS	SPOP	0.631	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	2039:2043	AESSS	SPOP	0.9996	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	4995:4999	AESSS	SPOP	0.9626	More...
Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	DEG_SPOP_SBC_1	423:427	AESSS	SPOP	0.9784	More...
Q68EM7	Rho GTPase-activating protein 17	DEG_SPOP_SBC_1	549:553	AESSS	SPOP	0.9662	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	416:420	AESSS	SPOP	0.8744	More...
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_SPOP_SBC_1	483:487	AESSS	SPOP	0.8917	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	712:716	AESSS	SPOP	0.6639	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	327:331	AESSS	SPOP	0.9547	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	877:881	AESSS	SPOP	0.7427	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10859:10863	AESSS	SPOP	0.9546	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11301:11305	AESSS	SPOP	0.5459	More...
Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	DEG_SPOP_SBC_1	346:350	AESSS	SPOP	0.9802	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	122:126	AESSS	SPOP	0.5091	More...
Q9BRP0	Transcription factor Ovo-like 2	DEG_SPOP_SBC_1	68:72	AESSS	SPOP	0.7978	More...
Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	DEG_SPOP_SBC_1	243:247	AESSS	SPOP	0.9849	More...
Q9UL62	Short transient receptor potential channel 5	DEG_SPOP_SBC_1	829:833	AESSS	SPOP	0.9986	More...
Q9UQ88	Cyclin-dependent kinase 11A	DEG_SPOP_SBC_1	280:284	AESSS	SPOP	0.9779	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1356:1360	AESSS	SPOP	0.9966	More...
Q9Y4J8	Dystrobrevin alpha	DEG_SPOP_SBC_1	446:450	AESSS	SPOP	0.8361	More...
Q6ZU80	Centrosomal protein of 128 kDa	DEG_SPOP_SBC_1	2:6	AESSS	SPOP	0.5106	More...
Q93073	Selenocysteine insertion sequence-binding protein 2-like	DEG_SPOP_SBC_1	255:259	AESSS	SPOP	0.9947	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	318:322	AESSS	SPOP	0.8116	More...
Q6NV74	CRACD-like protein	DEG_SPOP_SBC_1	213:217	AESSS	SPOP	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AESSS

Degron related mutations and impact score

Drug responses associated with RAPGEF2 mutations

All proteins holding degron of AESSS