DegronMD - Q8IVF5(TIAM2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E481Q	TCGA-2F-A9KT	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.E481Q	DO51863	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2778
p.T203P	TCGA-2Y-A9H1	LIHC	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.25
p.T203P	DO219521	LIHC	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.25
p.R156C	TCGA-4Z-AA82	BLCA	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2778
p.R156C	DO218987	BLCA	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2778
p.P152Q	TCGA-50-5930	LUAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.5924
p.P152Q	DO25189	LUAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.5924
p.L493M	TCGA-55-7728	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.L493M	DO25143	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.Q196K	TCGA-97-7938	LUAD	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.0556
p.Q196K	DO24329	LUAD	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.0556
p.K1017N	TCGA-A5-A2K5	UCEC	TCGA	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.2778
p.K1017N	TCGA-AX-A05Z	UCEC	TCGA	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.2778
p.K1017N	DO40884	UCEC	ICGC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.2778
p.K1017N	DO41379	UCEC	ICGC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.2778
p.D221N	TCGA-AA-3815	COAD	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1389
p.D221N	TCGA-AX-A2HC	UCEC	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1389
p.D221N	DO9924	COAD	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1389
p.D221N	DO41572	UCEC	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1389
p.G142R	TCGA-AC-A3OD	BRCA	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.G142R	TCGA-CK-6746	COAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.G142R	DO2365	BRCA	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.G142R	DO7938	COAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.R156H	TCGA-AZ-4315	COAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2778
p.R156H	DO8842	COAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2778
p.P152L	TCGA-BR-4368	STAD	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.6471
p.P152L	DO38715	STAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.6471
p.A483T	TCGA-BR-8590	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7139
p.A483T	TCGA-FD-A5BV	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7139
p.A483T	DO44036	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7139
p.A483T	DO47779	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.7139
p.S206L	TCGA-C8-A1HM	BRCA	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7667
p.S206L	TCGA-W3-AA1Q	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7667
p.S206L	DO3904	BRCA	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7667
p.S206L	DO219487	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7667
p.A220T	TCGA-CD-8531	STAD	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1667
p.A220T	DO47877	STAD	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1667
p.A220T	SIDM00710	Small Cell Lung Carcinoma	GDSC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1667
p.A220T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1667
p.T480S	TCGA-DD-AAC8	LIHC	TCGA	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.25
p.T480S	DO52193	LIHC	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.25
p.S149T	TCGA-EE-A29G	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7116
p.S149T	DO47303	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7116
p.P210T	TCGA-EE-A2A6	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.5919
p.P210T	DO37591	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.5919
p.P210L	TCGA-EE-A2GJ	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.6471
p.P210L	DO37746	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.6471
p.G142W	TCGA-EE-A2MG	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.G142W	DO37421	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.G142E	TCGA-EO-A3B0	UCEC	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.G142E	DO219773	UCEC	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.R1035M	TCGA-EY-A1GI	UCEC	TCGA	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.1667
p.R143K	TCGA-FG-A4MW	LGG	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2222
p.R143K	DO44602	LGG	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2222
p.K157N	TCGA-FR-A726	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation substituting flanking lysine	0.3611
p.K157N	DO48665	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation substituting flanking lysine	0.3611
p.E484K	TCGA-FS-A1ZE	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.591
p.E484K	DO37843	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation altering degron motif	0.591
p.S149F	TCGA-FW-A3R5	SKCM	TCGA	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7982
p.S149F	DO37406	SKCM	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7982
p.A214T	TCGA-FW-A3R5	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7139
p.A214T	DO37406	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7139
p.D1028H	TCGA-KU-A6H7	HNSC	TCGA	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation altering degron motif	0.7688
p.Y222C	DO48398	BLCA	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.1111
p.D146E	DO10164	COAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.3056
p.T150A	DO234183	ESAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.825
p.P210S	DO233898	GACA	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.5641
p.P202S	DO233823	GACA	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.2222
p.G163V	DO22566	LGG	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.0833
p.R143M	DO228948	LICA	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.2222
p.G478C	DO229034	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1944
p.P140S	DO49705	LIHC	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1389
p.D497N	DO222647	MELA	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0556
p.TE202TK	DO222775	MELA	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0
p.V203M	DO219303	PRAD	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.25
p.E203K	DO47665	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.25
p.H142R	DO38380	STAD	ICGC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1944
p.L479S	DO38619	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.2222
p.E223D	DO40889	UCEC	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.0833
p.M208T	DO41999	UCEC	ICGC	SETSPVPEA	DEG_COP1_1	206:214	Mutation altering degron motif	0.7423
p.S146N	SIDM02021	Esophageal Carcinoma	GDSC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.3056
p.V1026L	SIDM00697	Small Cell Lung Carcinoma	GDSC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation altering degron motif	0.6765
p.V1026L	NCI-H1436	lung	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation altering degron motif	0.6765
p.I476V	SIDM00631	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1389
p.I476V	MDA-MB-330	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1389
p.L162R	SIDM01064	Hodgkin's Lymphoma	GDSC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1111
p.L137H	SIDM01042	Breast Carcinoma	GDSC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.0556
p.L137H	ACH-001065	Breast Cancer	CCLE	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.0556
p.L137H	EVSA-T	breast	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.0556
p.K1016N	SIDM00118	Colorectal Carcinoma	GDSC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation substituting flanking lysine	0.3611
p.K1016N	HCC2998	large intestine	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation substituting flanking lysine	0.3611
p.T1031K	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.2778
p.T1031K	NCI-H1793	lung	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.2778
p.V150F	ACH-000648	Lung Cancer	CCLE	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7068
p.V150F	NCI-H28	pleura	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7068
p.R140Q	ACH-000666	Lung Cancer	CCLE	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1389
p.R140Q	NCI-H1355	lung	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1389
p.R1020Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation altering degron motif	0.7329
p.D1013N	ACH-001127	Leukemia	CCLE	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.1667
p.D1013N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.1667
p.P139T	NCI-H345	lung	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1111
p.D1018E	HCT-15	large intestine	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.3056
p.K160E	D-502MG	central nervous system	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1667
p.S160N	MDA-MB-453	breast	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation rewiring degron network	0.1667
p.G1011R	SNU-1040	large intestine	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation rewiring degron network	0.1111
p.A217E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.25
p.E496D	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.0833
p.E197K	RCC-AB	kidney	COSMIC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.0833
p.F216V	FLO-1	oesophagus	COSMIC	SETSPVPEA	DEG_COP1_1	206:214	Mutation rewiring degron network	0.2778
p.P477T	HCC1419	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	483:487	Mutation rewiring degron network	0.1667
p.P1026S	C32	skin	COSMIC	TANDFSNVPDI	DEG_COP1_1	1019:1029	Mutation altering degron motif	0.6752
p.C152F	EB-3	haematopoietic and lymphoid tissue	COSMIC	IASTPPGE	DEG_SCF_FBW7_2	147:154	Mutation altering degron motif	0.7108

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TIAM2

UniProt ID: Q8IVF5

Entrez ID: 26230

Protein name: Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TIAM2 in