DegronMD

Uniprot ID: Q8IVF5

Source protein: Rho guanine nucleotide exchange factor TIAM2

Source gene: TIAM2

Class: DEG_COP1_1

Location: 1019:1029

E3 ligase: COP1

DEGRON score: 0.9894

ASA_SCORE: 73.7364

COIL: 0.8235

CONS_SCORE: 0.4678

DSS_SCORE: 0.4576

HELIX: 0.1088

FCONS_SCORE: 1.0233

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1017N	TCGA-A5-A2K5	UCEC	TCGA	TANDFSNVPDI	DEG_COP1_1	0.2778
p.K1017N	TCGA-AX-A05Z	UCEC	TCGA	TANDFSNVPDI	DEG_COP1_1	0.2778
p.K1017N	DO40884	UCEC	ICGC	TANDFSNVPDI	DEG_COP1_1	0.2778
p.K1017N	DO41379	UCEC	ICGC	TANDFSNVPDI	DEG_COP1_1	0.2778
p.R1035M	TCGA-EY-A1GI	UCEC	TCGA	TANDFSNVPDI	DEG_COP1_1	0.1667
p.D1028H	TCGA-KU-A6H7	HNSC	TCGA	TANDFSNVPDI	DEG_COP1_1	0.7688
p.V1026L	SIDM00697	Small Cell Lung Carcinoma	GDSC	TANDFSNVPDI	DEG_COP1_1	0.6765
p.V1026L	NCI-H1436	lung	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.6765
p.K1016N	SIDM00118	Colorectal Carcinoma	GDSC	TANDFSNVPDI	DEG_COP1_1	0.3611
p.K1016N	HCC2998	large_intestine	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.3611
p.T1031K	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	TANDFSNVPDI	DEG_COP1_1	0.2778
p.T1031K	NCI-H1793	lung	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.2778
p.R1020Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	TANDFSNVPDI	DEG_COP1_1	0.7329
p.D1013N	ACH-001127	Leukemia	CCLE	TANDFSNVPDI	DEG_COP1_1	0.1667
p.D1013N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.1667
p.D1018E	HCT-15	large_intestine	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.3056
p.G1011R	SNU-1040	large_intestine	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.1111
p.P1026S	C32	skin	COSMIC	TANDFSNVPDI	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_COP1_1	1019:1029	TANDFSNVPDI	COP1	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons