DegronMD

Uniprot ID: Q8IVF5

Source protein: Rho guanine nucleotide exchange factor TIAM2

Source gene: TIAM2

Class: DEG_COP1_1

Location: 206:214

E3 ligase: COP1

DEGRON score: 0.9803

ASA_SCORE: 81.8111

COIL: 0.8749

CONS_SCORE: 0.3393

DSS_SCORE: 0.6545

HELIX: 0.0957

FCONS_SCORE: 0.976

RIG_SCORE: 0.6232

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T203P	TCGA-2Y-A9H1	LIHC	TCGA	SETSPVPEA	DEG_COP1_1	0.25
p.T203P	DO219521	LIHC	ICGC	SETSPVPEA	DEG_COP1_1	0.25
p.Q196K	TCGA-97-7938	LUAD	TCGA	SETSPVPEA	DEG_COP1_1	0.0556
p.Q196K	DO24329	LUAD	ICGC	SETSPVPEA	DEG_COP1_1	0.0556
p.D221N	TCGA-AA-3815	COAD	TCGA	SETSPVPEA	DEG_COP1_1	0.1389
p.D221N	TCGA-AX-A2HC	UCEC	TCGA	SETSPVPEA	DEG_COP1_1	0.1389
p.D221N	DO9924	COAD	ICGC	SETSPVPEA	DEG_COP1_1	0.1389
p.D221N	DO41572	UCEC	ICGC	SETSPVPEA	DEG_COP1_1	0.1389
p.S206L	TCGA-C8-A1HM	BRCA	TCGA	SETSPVPEA	DEG_COP1_1	0.7667
p.S206L	TCGA-W3-AA1Q	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	0.7667
p.S206L	DO3904	BRCA	ICGC	SETSPVPEA	DEG_COP1_1	0.7667
p.S206L	DO219487	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	0.7667
p.A220T	TCGA-CD-8531	STAD	TCGA	SETSPVPEA	DEG_COP1_1	0.1667
p.A220T	DO47877	STAD	ICGC	SETSPVPEA	DEG_COP1_1	0.1667
p.A220T	SIDM00710	Small Cell Lung Carcinoma	GDSC	SETSPVPEA	DEG_COP1_1	0.1667
p.A220T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SETSPVPEA	DEG_COP1_1	0.1667
p.P210T	TCGA-EE-A2A6	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	0.5919
p.P210T	DO37591	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	0.5919
p.P210L	TCGA-EE-A2GJ	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	0.6471
p.P210L	DO37746	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	0.6471
p.A214T	TCGA-FW-A3R5	SKCM	TCGA	SETSPVPEA	DEG_COP1_1	0.7139
p.A214T	DO37406	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	0.7139
p.Y222C	DO48398	BLCA	ICGC	SETSPVPEA	DEG_COP1_1	0.1111
p.P210S	DO233898	GACA	ICGC	SETSPVPEA	DEG_COP1_1	0.5641
p.P202S	DO233823	GACA	ICGC	SETSPVPEA	DEG_COP1_1	0.2222
p.TE202TK	DO222775	MELA	ICGC	SETSPVPEA	DEG_COP1_1	0
p.V203M	DO219303	PRAD	ICGC	SETSPVPEA	DEG_COP1_1	0.25
p.E203K	DO47665	SKCM	ICGC	SETSPVPEA	DEG_COP1_1	0.25
p.E223D	DO40889	UCEC	ICGC	SETSPVPEA	DEG_COP1_1	0.0833
p.M208T	DO41999	UCEC	ICGC	SETSPVPEA	DEG_COP1_1	0.7423
p.A217E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SETSPVPEA	DEG_COP1_1	0.25
p.E197K	RCC-AB	kidney	COSMIC	SETSPVPEA	DEG_COP1_1	0.0833
p.F216V	FLO-1	oesophagus	COSMIC	SETSPVPEA	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SETSPVPEA

Degron related mutations and impact score

Drug responses associated with TIAM2 mutations

All proteins holding degron of SETSPVPEA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF5	Rho guanine nucleotide exchange factor TIAM2	DEG_COP1_1	206:214	SETSPVPEA	COP1	0.9803	More...